Install packages

Install package:

if(!require(devtools)){
  install.packages("devtools") # If not already installed
}
#> Loading required package: devtools
devtools::install_github("TomKellyGenetics/DoubletDetection", ref = "r-implementation")
#> Skipping install of 'DoubletDetection' from a github remote, the SHA1 (2f420ba5) has not changed since last install.
#>   Use `force = TRUE` to force installation

Install dependancies:

#devtools::install_github("JinmiaoChenLab/Rphenograph")
devtools::install_github("TomKellyGenetics/Rphenograph")
install.packages("hdf5r")
install.packages("Matrix")

Install hdf5 (if needed)

OS X (using Homebrew) brew install hdf5

Debian-based systems (including Ubuntu) sudo apt-get install libhdf5-dev

Systems supporting yum and RPMs sudo yum install hdf5-devel

HDF5 1.8.14 has been pre-compiled for Windows and is available at https://github.com/mannau/h5-libwin

load package (and dependancies)

library("DoubletDetection")
#> Loading required package: Matrix
#> Loading required package: Rphenograph
#> Loading required package: gplots
#> 
#> Attaching package: 'gplots'
#> The following object is masked from 'package:stats':
#> 
#>     lowess
#> Loading required package: Rtsne
#> Warning: replacing previous import 'Matrix::cov2cor' by 'stats::cov2cor'
#> when loading 'DoubletDetection'
#> Warning: replacing previous import 'Matrix::toeplitz' by 'stats::toeplitz'
#> when loading 'DoubletDetection'
#> Warning: replacing previous import 'gplots::lowess' by 'stats::lowess' when
#> loading 'DoubletDetection'
#> Warning: replacing previous import 'Matrix::update' by 'stats::update' when
#> loading 'DoubletDetection'

Download Data from 10X Genomics

These commands will be called from R in Linux and Mac systems. The files will need to be downloaded from the given url (into the working directory) in Windows.

#download files
if(!(file.exists("pbmc8k_filtered_gene_bc_matrices.tar.gz"))){
  system("wget http://cf.10xgenomics.com/samples/cell-exp/2.1.0/pbmc8k/pbmc8k_filtered_gene_bc_matrices.tar.gz")
  #extract compressed files 
  #system("tar -xvzf pbmc8k_filtered_gene_bc_matrices.tar.gz")
}

Load Counts Matrix

matrix_path <- 'filtered_gene_bc_matrices/GRCh38/matrix.mtx'
raw_counts <- DoubletDetection::load_mtx(matrix_path)
# Remove columns with all 0s
non_zero_genes <- apply(raw_counts, 1, function(x) sum(x) != 0)
raw_counts <- raw_counts[non_zero_genes, ]

Run Doublet Detection

Right now, phenograph is a bit talkative, so we suppress the output to avoid lots of text:

#> Warning in .Object$initialize(...): numeric input for n_iters taken as an
#> integer
#> [1] "function sum accepted as new_lib_as"
#> [1] "Reference Class BoostClassifier has been initialized"
#> Warning in clf$fit(raw_counts): Sparse raw_counts is automatically
#> densified
#> [1] "Iteration 1/50"
#> [1] "Creating downsampled doublets..."
#> [1] "running downsamplePair for synthetic cell 1"
#> [1] "running downsamplePair for synthetic cell 2"
#> [1] "running downsamplePair for synthetic cell 3"
#> [1] "running downsamplePair for synthetic cell 4"
#> [1] "running downsamplePair for synthetic cell 5"
#> [1] "running downsamplePair for synthetic cell 6"
#> [1] "running downsamplePair for synthetic cell 7"
#> [1] "running downsamplePair for synthetic cell 8"
#> [1] "running downsamplePair for synthetic cell 9"
#> [1] "running downsamplePair for synthetic cell 10"
#> [1] "running downsamplePair for synthetic cell 11"
#> [1] "running downsamplePair for synthetic cell 12"
#> [1] "running downsamplePair for synthetic cell 13"
#> [1] "running downsamplePair for synthetic cell 14"
#> [1] "running downsamplePair for synthetic cell 15"
#> [1] "running downsamplePair for synthetic cell 16"
#> [1] "running downsamplePair for synthetic cell 17"
#> [1] "running downsamplePair for synthetic cell 18"
#> [1] "running downsamplePair for synthetic cell 19"
#> [1] "running downsamplePair for synthetic cell 20"
#> [1] "running downsamplePair for synthetic cell 21"
#> [1] "running downsamplePair for synthetic cell 22"
#> [1] "running downsamplePair for synthetic cell 23"
#> [1] "running downsamplePair for synthetic cell 24"
#> [1] "running downsamplePair for synthetic cell 25"
#> [1] "running downsamplePair for synthetic cell 26"
#> [1] "running downsamplePair for synthetic cell 27"
#> [1] "running downsamplePair for synthetic cell 28"
#> [1] "running downsamplePair for synthetic cell 29"
#> [1] "running downsamplePair for synthetic cell 30"
#> [1] "running downsamplePair for synthetic cell 31"
#> [1] "running downsamplePair for synthetic cell 32"
#> [1] "running downsamplePair for synthetic cell 33"
#> [1] "running downsamplePair for synthetic cell 34"
#> [1] "running downsamplePair for synthetic cell 35"
#> [1] "running downsamplePair for synthetic cell 36"
#> [1] "running downsamplePair for synthetic cell 37"
#> [1] "running downsamplePair for synthetic cell 38"
#> [1] "running downsamplePair for synthetic cell 39"
#> [1] "running downsamplePair for synthetic cell 40"
#> [1] "running downsamplePair for synthetic cell 41"
#> [1] "running downsamplePair for synthetic cell 42"
#> [1] "running downsamplePair for synthetic cell 43"
#> [1] "running downsamplePair for synthetic cell 44"
#> [1] "running downsamplePair for synthetic cell 45"
#> [1] "running downsamplePair for synthetic cell 46"
#> [1] "running downsamplePair for synthetic cell 47"
#> [1] "running downsamplePair for synthetic cell 48"
#> [1] "running downsamplePair for synthetic cell 49"
#> [1] "running downsamplePair for synthetic cell 50"
#> [1] "running downsamplePair for synthetic cell 51"
#> [1] "running downsamplePair for synthetic cell 52"
#> [1] "running downsamplePair for synthetic cell 53"
#> [1] "running downsamplePair for synthetic cell 54"
#> [1] "running downsamplePair for synthetic cell 55"
#> [1] "running downsamplePair for synthetic cell 56"
#> [1] "running downsamplePair for synthetic cell 57"
#> [1] "running downsamplePair for synthetic cell 58"
#> [1] "running downsamplePair for synthetic cell 59"
#> [1] "running downsamplePair for synthetic cell 60"
#> [1] "running downsamplePair for synthetic cell 61"
#> [1] "running downsamplePair for synthetic cell 62"
#> [1] "running downsamplePair for synthetic cell 63"
#> [1] "running downsamplePair for synthetic cell 64"
#> [1] "running downsamplePair for synthetic cell 65"
#> [1] "running downsamplePair for synthetic cell 66"
#> [1] "running downsamplePair for synthetic cell 67"
#> [1] "running downsamplePair for synthetic cell 68"
#> [1] "running downsamplePair for synthetic cell 69"
#> [1] "running downsamplePair for synthetic cell 70"
#> [1] "running downsamplePair for synthetic cell 71"
#> [1] "running downsamplePair for synthetic cell 72"
#> [1] "running downsamplePair for synthetic cell 73"
#> [1] "running downsamplePair for synthetic cell 74"
#> [1] "running downsamplePair for synthetic cell 75"
#> [1] "running downsamplePair for synthetic cell 76"
#> [1] "running downsamplePair for synthetic cell 77"
#> [1] "running downsamplePair for synthetic cell 78"
#> [1] "running downsamplePair for synthetic cell 79"
#> [1] "running downsamplePair for synthetic cell 80"
#> [1] "running downsamplePair for synthetic cell 81"
#> [1] "running downsamplePair for synthetic cell 82"
#> [1] "running downsamplePair for synthetic cell 83"
#> [1] "running downsamplePair for synthetic cell 84"
#> [1] "running downsamplePair for synthetic cell 85"
#> [1] "running downsamplePair for synthetic cell 86"
#> [1] "running downsamplePair for synthetic cell 87"
#> [1] "running downsamplePair for synthetic cell 88"
#> [1] "running downsamplePair for synthetic cell 89"
#> [1] "running downsamplePair for synthetic cell 90"
#> [1] "running downsamplePair for synthetic cell 91"
#> [1] "running downsamplePair for synthetic cell 92"
#> [1] "running downsamplePair for synthetic cell 93"
#> [1] "running downsamplePair for synthetic cell 94"
#> [1] "running downsamplePair for synthetic cell 95"
#> [1] "running downsamplePair for synthetic cell 96"
#> [1] "running downsamplePair for synthetic cell 97"
#> [1] "running downsamplePair for synthetic cell 98"
#> [1] "running downsamplePair for synthetic cell 99"
#> [1] "running downsamplePair for synthetic cell 100"
#> [1] "running downsamplePair for synthetic cell 101"
#> [1] "running downsamplePair for synthetic cell 102"
#> [1] "running downsamplePair for synthetic cell 103"
#> [1] "running downsamplePair for synthetic cell 104"
#> [1] "running downsamplePair for synthetic cell 105"
#> [1] "running downsamplePair for synthetic cell 106"
#> [1] "running downsamplePair for synthetic cell 107"
#> [1] "running downsamplePair for synthetic cell 108"
#> [1] "running downsamplePair for synthetic cell 109"
#> [1] "running downsamplePair for synthetic cell 110"
#> [1] "running downsamplePair for synthetic cell 111"
#> [1] "running downsamplePair for synthetic cell 112"
#> [1] "running downsamplePair for synthetic cell 113"
#> [1] "running downsamplePair for synthetic cell 114"
#> [1] "running downsamplePair for synthetic cell 115"
#> [1] "running downsamplePair for synthetic cell 116"
#> [1] "running downsamplePair for synthetic cell 117"
#> [1] "running downsamplePair for synthetic cell 118"
#> [1] "running downsamplePair for synthetic cell 119"
#> [1] "running downsamplePair for synthetic cell 120"
#> [1] "running downsamplePair for synthetic cell 121"
#> [1] "running downsamplePair for synthetic cell 122"
#> [1] "running downsamplePair for synthetic cell 123"
#> [1] "running downsamplePair for synthetic cell 124"
#> [1] "running downsamplePair for synthetic cell 125"
#> [1] "running downsamplePair for synthetic cell 126"
#> [1] "running downsamplePair for synthetic cell 127"
#> [1] "running downsamplePair for synthetic cell 128"
#> [1] "running downsamplePair for synthetic cell 129"
#> [1] "running downsamplePair for synthetic cell 130"
#> [1] "running downsamplePair for synthetic cell 131"
#> [1] "running downsamplePair for synthetic cell 132"
#> [1] "running downsamplePair for synthetic cell 133"
#> [1] "running downsamplePair for synthetic cell 134"
#> [1] "running downsamplePair for synthetic cell 135"
#> [1] "running downsamplePair for synthetic cell 136"
#> [1] "running downsamplePair for synthetic cell 137"
#> [1] "running downsamplePair for synthetic cell 138"
#> [1] "running downsamplePair for synthetic cell 139"
#> [1] "running downsamplePair for synthetic cell 140"
#> [1] "running downsamplePair for synthetic cell 141"
#> [1] "running downsamplePair for synthetic cell 142"
#> [1] "running downsamplePair for synthetic cell 143"
#> [1] "running downsamplePair for synthetic cell 144"
#> [1] "running downsamplePair for synthetic cell 145"
#> [1] "running downsamplePair for synthetic cell 146"
#> [1] "running downsamplePair for synthetic cell 147"
#> [1] "running downsamplePair for synthetic cell 148"
#> [1] "running downsamplePair for synthetic cell 149"
#> [1] "running downsamplePair for synthetic cell 150"
#> [1] "running downsamplePair for synthetic cell 151"
#> [1] "running downsamplePair for synthetic cell 152"
#> [1] "running downsamplePair for synthetic cell 153"
#> [1] "running downsamplePair for synthetic cell 154"
#> [1] "running downsamplePair for synthetic cell 155"
#> [1] "running downsamplePair for synthetic cell 156"
#> [1] "running downsamplePair for synthetic cell 157"
#> [1] "running downsamplePair for synthetic cell 158"
#> [1] "running downsamplePair for synthetic cell 159"
#> [1] "running downsamplePair for synthetic cell 160"
#> [1] "running downsamplePair for synthetic cell 161"
#> [1] "running downsamplePair for synthetic cell 162"
#> [1] "running downsamplePair for synthetic cell 163"
#> [1] "running downsamplePair for synthetic cell 164"
#> [1] "running downsamplePair for synthetic cell 165"
#> [1] "running downsamplePair for synthetic cell 166"
#> [1] "running downsamplePair for synthetic cell 167"
#> [1] "running downsamplePair for synthetic cell 168"
#> [1] "running downsamplePair for synthetic cell 169"
#> [1] "running downsamplePair for synthetic cell 170"
#> [1] "running downsamplePair for synthetic cell 171"
#> [1] "running downsamplePair for synthetic cell 172"
#> [1] "running downsamplePair for synthetic cell 173"
#> [1] "running downsamplePair for synthetic cell 174"
#> [1] "running downsamplePair for synthetic cell 175"
#> [1] "running downsamplePair for synthetic cell 176"
#> [1] "running downsamplePair for synthetic cell 177"
#> [1] "running downsamplePair for synthetic cell 178"
#> [1] "running downsamplePair for synthetic cell 179"
#> [1] "running downsamplePair for synthetic cell 180"
#> [1] "running downsamplePair for synthetic cell 181"
#> [1] "running downsamplePair for synthetic cell 182"
#> [1] "running downsamplePair for synthetic cell 183"
#> [1] "running downsamplePair for synthetic cell 184"
#> [1] "running downsamplePair for synthetic cell 185"
#> [1] "running downsamplePair for synthetic cell 186"
#> [1] "running downsamplePair for synthetic cell 187"
#> [1] "running downsamplePair for synthetic cell 188"
#> [1] "running downsamplePair for synthetic cell 189"
#> [1] "running downsamplePair for synthetic cell 190"
#> [1] "running downsamplePair for synthetic cell 191"
#> [1] "running downsamplePair for synthetic cell 192"
#> [1] "running downsamplePair for synthetic cell 193"
#> [1] "running downsamplePair for synthetic cell 194"
#> [1] "running downsamplePair for synthetic cell 195"
#> [1] "running downsamplePair for synthetic cell 196"
#> [1] "running downsamplePair for synthetic cell 197"
#> [1] "running downsamplePair for synthetic cell 198"
#> [1] "running downsamplePair for synthetic cell 199"
#> [1] "running downsamplePair for synthetic cell 200"
#> [1] "running downsamplePair for synthetic cell 201"
#> [1] "running downsamplePair for synthetic cell 202"
#> [1] "running downsamplePair for synthetic cell 203"
#> [1] "running downsamplePair for synthetic cell 204"
#> [1] "running downsamplePair for synthetic cell 205"
#> [1] "running downsamplePair for synthetic cell 206"
#> [1] "running downsamplePair for synthetic cell 207"
#> [1] "running downsamplePair for synthetic cell 208"
#> [1] "running downsamplePair for synthetic cell 209"
#> [1] "running downsamplePair for synthetic cell 210"
#> [1] "running downsamplePair for synthetic cell 211"
#> [1] "running downsamplePair for synthetic cell 212"
#> [1] "running downsamplePair for synthetic cell 213"
#> [1] "running downsamplePair for synthetic cell 214"
#> [1] "running downsamplePair for synthetic cell 215"
#> [1] "running downsamplePair for synthetic cell 216"
#> [1] "running downsamplePair for synthetic cell 217"
#> [1] "running downsamplePair for synthetic cell 218"
#> [1] "running downsamplePair for synthetic cell 219"
#> [1] "running downsamplePair for synthetic cell 220"
#> [1] "running downsamplePair for synthetic cell 221"
#> [1] "running downsamplePair for synthetic cell 222"
#> [1] "running downsamplePair for synthetic cell 223"
#> [1] "running downsamplePair for synthetic cell 224"
#> [1] "running downsamplePair for synthetic cell 225"
#> [1] "running downsamplePair for synthetic cell 226"
#> [1] "running downsamplePair for synthetic cell 227"
#> [1] "running downsamplePair for synthetic cell 228"
#> [1] "running downsamplePair for synthetic cell 229"
#> [1] "running downsamplePair for synthetic cell 230"
#> [1] "running downsamplePair for synthetic cell 231"
#> [1] "running downsamplePair for synthetic cell 232"
#> [1] "running downsamplePair for synthetic cell 233"
#> [1] "running downsamplePair for synthetic cell 234"
#> [1] "running downsamplePair for synthetic cell 235"
#> [1] "running downsamplePair for synthetic cell 236"
#> [1] "running downsamplePair for synthetic cell 237"
#> [1] "running downsamplePair for synthetic cell 238"
#> [1] "running downsamplePair for synthetic cell 239"
#> [1] "running downsamplePair for synthetic cell 240"
#> [1] "running downsamplePair for synthetic cell 241"
#> [1] "running downsamplePair for synthetic cell 242"
#> [1] "running downsamplePair for synthetic cell 243"
#> [1] "running downsamplePair for synthetic cell 244"
#> [1] "running downsamplePair for synthetic cell 245"
#> [1] "running downsamplePair for synthetic cell 246"
#> [1] "running downsamplePair for synthetic cell 247"
#> [1] "running downsamplePair for synthetic cell 248"
#> [1] "running downsamplePair for synthetic cell 249"
#> [1] "running downsamplePair for synthetic cell 250"
#> [1] "running downsamplePair for synthetic cell 251"
#> [1] "running downsamplePair for synthetic cell 252"
#> [1] "running downsamplePair for synthetic cell 253"
#> [1] "running downsamplePair for synthetic cell 254"
#> [1] "running downsamplePair for synthetic cell 255"
#> [1] "running downsamplePair for synthetic cell 256"
#> [1] "running downsamplePair for synthetic cell 257"
#> [1] "running downsamplePair for synthetic cell 258"
#> [1] "running downsamplePair for synthetic cell 259"
#> [1] "running downsamplePair for synthetic cell 260"
#> [1] "running downsamplePair for synthetic cell 261"
#> [1] "running downsamplePair for synthetic cell 262"
#> [1] "running downsamplePair for synthetic cell 263"
#> [1] "running downsamplePair for synthetic cell 264"
#> [1] "running downsamplePair for synthetic cell 265"
#> [1] "running downsamplePair for synthetic cell 266"
#> [1] "running downsamplePair for synthetic cell 267"
#> [1] "running downsamplePair for synthetic cell 268"
#> [1] "running downsamplePair for synthetic cell 269"
#> [1] "running downsamplePair for synthetic cell 270"
#> [1] "running downsamplePair for synthetic cell 271"
#> [1] "running downsamplePair for synthetic cell 272"
#> [1] "running downsamplePair for synthetic cell 273"
#> [1] "running downsamplePair for synthetic cell 274"
#> [1] "running downsamplePair for synthetic cell 275"
#> [1] "running downsamplePair for synthetic cell 276"
#> [1] "running downsamplePair for synthetic cell 277"
#> [1] "running downsamplePair for synthetic cell 278"
#> [1] "running downsamplePair for synthetic cell 279"
#> [1] "running downsamplePair for synthetic cell 280"
#> [1] "running downsamplePair for synthetic cell 281"
#> [1] "running downsamplePair for synthetic cell 282"
#> [1] "running downsamplePair for synthetic cell 283"
#> [1] "running downsamplePair for synthetic cell 284"
#> [1] "running downsamplePair for synthetic cell 285"
#> [1] "running downsamplePair for synthetic cell 286"
#> [1] "running downsamplePair for synthetic cell 287"
#> [1] "running downsamplePair for synthetic cell 288"
#> [1] "running downsamplePair for synthetic cell 289"
#> [1] "running downsamplePair for synthetic cell 290"
#> [1] "running downsamplePair for synthetic cell 291"
#> [1] "running downsamplePair for synthetic cell 292"
#> [1] "running downsamplePair for synthetic cell 293"
#> [1] "running downsamplePair for synthetic cell 294"
#> [1] "running downsamplePair for synthetic cell 295"
#> [1] "running downsamplePair for synthetic cell 296"
#> [1] "running downsamplePair for synthetic cell 297"
#> [1] "running downsamplePair for synthetic cell 298"
#> [1] "running downsamplePair for synthetic cell 299"
#> [1] "running downsamplePair for synthetic cell 300"
#> [1] "running downsamplePair for synthetic cell 301"
#> [1] "running downsamplePair for synthetic cell 302"
#> [1] "running downsamplePair for synthetic cell 303"
#> [1] "running downsamplePair for synthetic cell 304"
#> [1] "running downsamplePair for synthetic cell 305"
#> [1] "running downsamplePair for synthetic cell 306"
#> [1] "running downsamplePair for synthetic cell 307"
#> [1] "running downsamplePair for synthetic cell 308"
#> [1] "running downsamplePair for synthetic cell 309"
#> [1] "running downsamplePair for synthetic cell 310"
#> [1] "running downsamplePair for synthetic cell 311"
#> [1] "running downsamplePair for synthetic cell 312"
#> [1] "running downsamplePair for synthetic cell 313"
#> [1] "running downsamplePair for synthetic cell 314"
#> [1] "running downsamplePair for synthetic cell 315"
#> [1] "running downsamplePair for synthetic cell 316"
#> [1] "running downsamplePair for synthetic cell 317"
#> [1] "running downsamplePair for synthetic cell 318"
#> [1] "running downsamplePair for synthetic cell 319"
#> [1] "running downsamplePair for synthetic cell 320"
#> [1] "running downsamplePair for synthetic cell 321"
#> [1] "running downsamplePair for synthetic cell 322"
#> [1] "running downsamplePair for synthetic cell 323"
#> [1] "running downsamplePair for synthetic cell 324"
#> [1] "running downsamplePair for synthetic cell 325"
#> [1] "running downsamplePair for synthetic cell 326"
#> [1] "running downsamplePair for synthetic cell 327"
#> [1] "running downsamplePair for synthetic cell 328"
#> [1] "running downsamplePair for synthetic cell 329"
#> [1] "running downsamplePair for synthetic cell 330"
#> [1] "running downsamplePair for synthetic cell 331"
#> [1] "running downsamplePair for synthetic cell 332"
#> [1] "running downsamplePair for synthetic cell 333"
#> [1] "running downsamplePair for synthetic cell 334"
#> [1] "running downsamplePair for synthetic cell 335"
#> [1] "running downsamplePair for synthetic cell 336"
#> [1] "running downsamplePair for synthetic cell 337"
#> [1] "running downsamplePair for synthetic cell 338"
#> [1] "running downsamplePair for synthetic cell 339"
#> [1] "running downsamplePair for synthetic cell 340"
#> [1] "running downsamplePair for synthetic cell 341"
#> [1] "running downsamplePair for synthetic cell 342"
#> [1] "running downsamplePair for synthetic cell 343"
#> [1] "running downsamplePair for synthetic cell 344"
#> [1] "running downsamplePair for synthetic cell 345"
#> [1] "running downsamplePair for synthetic cell 346"
#> [1] "running downsamplePair for synthetic cell 347"
#> [1] "running downsamplePair for synthetic cell 348"
#> [1] "running downsamplePair for synthetic cell 349"
#> [1] "running downsamplePair for synthetic cell 350"
#> [1] "running downsamplePair for synthetic cell 351"
#> [1] "running downsamplePair for synthetic cell 352"
#> [1] "running downsamplePair for synthetic cell 353"
#> [1] "running downsamplePair for synthetic cell 354"
#> [1] "running downsamplePair for synthetic cell 355"
#> [1] "running downsamplePair for synthetic cell 356"
#> [1] "running downsamplePair for synthetic cell 357"
#> [1] "running downsamplePair for synthetic cell 358"
#> [1] "running downsamplePair for synthetic cell 359"
#> [1] "running downsamplePair for synthetic cell 360"
#> [1] "running downsamplePair for synthetic cell 361"
#> [1] "running downsamplePair for synthetic cell 362"
#> [1] "running downsamplePair for synthetic cell 363"
#> [1] "running downsamplePair for synthetic cell 364"
#> [1] "running downsamplePair for synthetic cell 365"
#> [1] "running downsamplePair for synthetic cell 366"
#> [1] "running downsamplePair for synthetic cell 367"
#> [1] "running downsamplePair for synthetic cell 368"
#> [1] "running downsamplePair for synthetic cell 369"
#> [1] "running downsamplePair for synthetic cell 370"
#> [1] "running downsamplePair for synthetic cell 371"
#> [1] "running downsamplePair for synthetic cell 372"
#> [1] "running downsamplePair for synthetic cell 373"
#> [1] "running downsamplePair for synthetic cell 374"
#> [1] "running downsamplePair for synthetic cell 375"
#> [1] "running downsamplePair for synthetic cell 376"
#> [1] "running downsamplePair for synthetic cell 377"
#> [1] "running downsamplePair for synthetic cell 378"
#> [1] "running downsamplePair for synthetic cell 379"
#> [1] "running downsamplePair for synthetic cell 380"
#> [1] "running downsamplePair for synthetic cell 381"
#> [1] "running downsamplePair for synthetic cell 382"
#> [1] "running downsamplePair for synthetic cell 383"
#> [1] "running downsamplePair for synthetic cell 384"
#> [1] "running downsamplePair for synthetic cell 385"
#> [1] "running downsamplePair for synthetic cell 386"
#> [1] "running downsamplePair for synthetic cell 387"
#> [1] "running downsamplePair for synthetic cell 388"
#> [1] "running downsamplePair for synthetic cell 389"
#> [1] "running downsamplePair for synthetic cell 390"
#> [1] "running downsamplePair for synthetic cell 391"
#> [1] "running downsamplePair for synthetic cell 392"
#> [1] "running downsamplePair for synthetic cell 393"
#> [1] "running downsamplePair for synthetic cell 394"
#> [1] "running downsamplePair for synthetic cell 395"
#> [1] "running downsamplePair for synthetic cell 396"
#> [1] "running downsamplePair for synthetic cell 397"
#> [1] "running downsamplePair for synthetic cell 398"
#> [1] "running downsamplePair for synthetic cell 399"
#> [1] "running downsamplePair for synthetic cell 400"
#> [1] "running downsamplePair for synthetic cell 401"
#> [1] "running downsamplePair for synthetic cell 402"
#> [1] "running downsamplePair for synthetic cell 403"
#> [1] "running downsamplePair for synthetic cell 404"
#> [1] "running downsamplePair for synthetic cell 405"
#> [1] "running downsamplePair for synthetic cell 406"
#> [1] "running downsamplePair for synthetic cell 407"
#> [1] "running downsamplePair for synthetic cell 408"
#> [1] "running downsamplePair for synthetic cell 409"
#> [1] "running downsamplePair for synthetic cell 410"
#> [1] "running downsamplePair for synthetic cell 411"
#> [1] "running downsamplePair for synthetic cell 412"
#> [1] "running downsamplePair for synthetic cell 413"
#> [1] "running downsamplePair for synthetic cell 414"
#> [1] "running downsamplePair for synthetic cell 415"
#> [1] "running downsamplePair for synthetic cell 416"
#> [1] "running downsamplePair for synthetic cell 417"
#> [1] "running downsamplePair for synthetic cell 418"
#> [1] "running downsamplePair for synthetic cell 419"
#> [1] "running downsamplePair for synthetic cell 420"
#> [1] "running downsamplePair for synthetic cell 421"
#> [1] "running downsamplePair for synthetic cell 422"
#> [1] "running downsamplePair for synthetic cell 423"
#> [1] "running downsamplePair for synthetic cell 424"
#> [1] "running downsamplePair for synthetic cell 425"
#> [1] "running downsamplePair for synthetic cell 426"
#> [1] "running downsamplePair for synthetic cell 427"
#> [1] "running downsamplePair for synthetic cell 428"
#> [1] "running downsamplePair for synthetic cell 429"
#> [1] "running downsamplePair for synthetic cell 430"
#> [1] "running downsamplePair for synthetic cell 431"
#> [1] "running downsamplePair for synthetic cell 432"
#> [1] "running downsamplePair for synthetic cell 433"
#> [1] "running downsamplePair for synthetic cell 434"
#> [1] "running downsamplePair for synthetic cell 435"
#> [1] "running downsamplePair for synthetic cell 436"
#> [1] "running downsamplePair for synthetic cell 437"
#> [1] "running downsamplePair for synthetic cell 438"
#> [1] "running downsamplePair for synthetic cell 439"
#> [1] "running downsamplePair for synthetic cell 440"
#> [1] "running downsamplePair for synthetic cell 441"
#> [1] "running downsamplePair for synthetic cell 442"
#> [1] "running downsamplePair for synthetic cell 443"
#> [1] "running downsamplePair for synthetic cell 444"
#> [1] "running downsamplePair for synthetic cell 445"
#> [1] "running downsamplePair for synthetic cell 446"
#> [1] "running downsamplePair for synthetic cell 447"
#> [1] "running downsamplePair for synthetic cell 448"
#> [1] "running downsamplePair for synthetic cell 449"
#> [1] "running downsamplePair for synthetic cell 450"
#> [1] "running downsamplePair for synthetic cell 451"
#> [1] "running downsamplePair for synthetic cell 452"
#> [1] "running downsamplePair for synthetic cell 453"
#> [1] "running downsamplePair for synthetic cell 454"
#> [1] "running downsamplePair for synthetic cell 455"
#> [1] "running downsamplePair for synthetic cell 456"
#> [1] "running downsamplePair for synthetic cell 457"
#> [1] "running downsamplePair for synthetic cell 458"
#> [1] "running downsamplePair for synthetic cell 459"
#> [1] "running downsamplePair for synthetic cell 460"
#> [1] "running downsamplePair for synthetic cell 461"
#> [1] "running downsamplePair for synthetic cell 462"
#> [1] "running downsamplePair for synthetic cell 463"
#> [1] "running downsamplePair for synthetic cell 464"
#> [1] "running downsamplePair for synthetic cell 465"
#> [1] "running downsamplePair for synthetic cell 466"
#> [1] "running downsamplePair for synthetic cell 467"
#> [1] "running downsamplePair for synthetic cell 468"
#> [1] "running downsamplePair for synthetic cell 469"
#> [1] "running downsamplePair for synthetic cell 470"
#> [1] "running downsamplePair for synthetic cell 471"
#> [1] "running downsamplePair for synthetic cell 472"
#> [1] "running downsamplePair for synthetic cell 473"
#> [1] "running downsamplePair for synthetic cell 474"
#> [1] "running downsamplePair for synthetic cell 475"
#> [1] "running downsamplePair for synthetic cell 476"
#> [1] "running downsamplePair for synthetic cell 477"
#> [1] "running downsamplePair for synthetic cell 478"
#> [1] "running downsamplePair for synthetic cell 479"
#> [1] "running downsamplePair for synthetic cell 480"
#> [1] "running downsamplePair for synthetic cell 481"
#> [1] "running downsamplePair for synthetic cell 482"
#> [1] "running downsamplePair for synthetic cell 483"
#> [1] "running downsamplePair for synthetic cell 484"
#> [1] "running downsamplePair for synthetic cell 485"
#> [1] "running downsamplePair for synthetic cell 486"
#> [1] "running downsamplePair for synthetic cell 487"
#> [1] "running downsamplePair for synthetic cell 488"
#> [1] "running downsamplePair for synthetic cell 489"
#> [1] "running downsamplePair for synthetic cell 490"
#> [1] "running downsamplePair for synthetic cell 491"
#> [1] "running downsamplePair for synthetic cell 492"
#> [1] "running downsamplePair for synthetic cell 493"
#> [1] "running downsamplePair for synthetic cell 494"
#> [1] "running downsamplePair for synthetic cell 495"
#> [1] "running downsamplePair for synthetic cell 496"
#> [1] "running downsamplePair for synthetic cell 497"
#> [1] "running downsamplePair for synthetic cell 498"
#> [1] "running downsamplePair for synthetic cell 499"
#> [1] "running downsamplePair for synthetic cell 500"
#> [1] "running downsamplePair for synthetic cell 501"
#> [1] "running downsamplePair for synthetic cell 502"
#> [1] "running downsamplePair for synthetic cell 503"
#> [1] "running downsamplePair for synthetic cell 504"
#> [1] "running downsamplePair for synthetic cell 505"
#> [1] "running downsamplePair for synthetic cell 506"
#> [1] "running downsamplePair for synthetic cell 507"
#> [1] "running downsamplePair for synthetic cell 508"
#> [1] "running downsamplePair for synthetic cell 509"
#> [1] "running downsamplePair for synthetic cell 510"
#> [1] "running downsamplePair for synthetic cell 511"
#> [1] "running downsamplePair for synthetic cell 512"
#> [1] "running downsamplePair for synthetic cell 513"
#> [1] "running downsamplePair for synthetic cell 514"
#> [1] "running downsamplePair for synthetic cell 515"
#> [1] "running downsamplePair for synthetic cell 516"
#> [1] "running downsamplePair for synthetic cell 517"
#> [1] "running downsamplePair for synthetic cell 518"
#> [1] "running downsamplePair for synthetic cell 519"
#> [1] "running downsamplePair for synthetic cell 520"
#> [1] "running downsamplePair for synthetic cell 521"
#> [1] "running downsamplePair for synthetic cell 522"
#> [1] "running downsamplePair for synthetic cell 523"
#> [1] "running downsamplePair for synthetic cell 524"
#> [1] "running downsamplePair for synthetic cell 525"
#> [1] "running downsamplePair for synthetic cell 526"
#> [1] "running downsamplePair for synthetic cell 527"
#> [1] "running downsamplePair for synthetic cell 528"
#> [1] "running downsamplePair for synthetic cell 529"
#> [1] "running downsamplePair for synthetic cell 530"
#> [1] "running downsamplePair for synthetic cell 531"
#> [1] "running downsamplePair for synthetic cell 532"
#> [1] "running downsamplePair for synthetic cell 533"
#> [1] "running downsamplePair for synthetic cell 534"
#> [1] "running downsamplePair for synthetic cell 535"
#> [1] "running downsamplePair for synthetic cell 536"
#> [1] "running downsamplePair for synthetic cell 537"
#> [1] "running downsamplePair for synthetic cell 538"
#> [1] "running downsamplePair for synthetic cell 539"
#> [1] "running downsamplePair for synthetic cell 540"
#> [1] "running downsamplePair for synthetic cell 541"
#> [1] "running downsamplePair for synthetic cell 542"
#> [1] "running downsamplePair for synthetic cell 543"
#> [1] "running downsamplePair for synthetic cell 544"
#> [1] "running downsamplePair for synthetic cell 545"
#> [1] "running downsamplePair for synthetic cell 546"
#> [1] "running downsamplePair for synthetic cell 547"
#> [1] "running downsamplePair for synthetic cell 548"
#> [1] "running downsamplePair for synthetic cell 549"
#> [1] "running downsamplePair for synthetic cell 550"
#> [1] "running downsamplePair for synthetic cell 551"
#> [1] "running downsamplePair for synthetic cell 552"
#> [1] "running downsamplePair for synthetic cell 553"
#> [1] "running downsamplePair for synthetic cell 554"
#> [1] "running downsamplePair for synthetic cell 555"
#> [1] "running downsamplePair for synthetic cell 556"
#> [1] "running downsamplePair for synthetic cell 557"
#> [1] "running downsamplePair for synthetic cell 558"
#> [1] "running downsamplePair for synthetic cell 559"
#> [1] "running downsamplePair for synthetic cell 560"
#> [1] "running downsamplePair for synthetic cell 561"
#> [1] "running downsamplePair for synthetic cell 562"
#> [1] "running downsamplePair for synthetic cell 563"
#> [1] "running downsamplePair for synthetic cell 564"
#> [1] "running downsamplePair for synthetic cell 565"
#> [1] "running downsamplePair for synthetic cell 566"
#> [1] "running downsamplePair for synthetic cell 567"
#> [1] "running downsamplePair for synthetic cell 568"
#> [1] "running downsamplePair for synthetic cell 569"
#> [1] "running downsamplePair for synthetic cell 570"
#> [1] "running downsamplePair for synthetic cell 571"
#> [1] "running downsamplePair for synthetic cell 572"
#> [1] "running downsamplePair for synthetic cell 573"
#> [1] "running downsamplePair for synthetic cell 574"
#> [1] "running downsamplePair for synthetic cell 575"
#> [1] "running downsamplePair for synthetic cell 576"
#> [1] "running downsamplePair for synthetic cell 577"
#> [1] "running downsamplePair for synthetic cell 578"
#> [1] "running downsamplePair for synthetic cell 579"
#> [1] "running downsamplePair for synthetic cell 580"
#> [1] "running downsamplePair for synthetic cell 581"
#> [1] "running downsamplePair for synthetic cell 582"
#> [1] "running downsamplePair for synthetic cell 583"
#> [1] "running downsamplePair for synthetic cell 584"
#> [1] "running downsamplePair for synthetic cell 585"
#> [1] "running downsamplePair for synthetic cell 586"
#> [1] "running downsamplePair for synthetic cell 587"
#> [1] "running downsamplePair for synthetic cell 588"
#> [1] "running downsamplePair for synthetic cell 589"
#> [1] "running downsamplePair for synthetic cell 590"
#> [1] "running downsamplePair for synthetic cell 591"
#> [1] "running downsamplePair for synthetic cell 592"
#> [1] "running downsamplePair for synthetic cell 593"
#> [1] "running downsamplePair for synthetic cell 594"
#> [1] "running downsamplePair for synthetic cell 595"
#> [1] "running downsamplePair for synthetic cell 596"
#> [1] "running downsamplePair for synthetic cell 597"
#> [1] "running downsamplePair for synthetic cell 598"
#> [1] "running downsamplePair for synthetic cell 599"
#> [1] "running downsamplePair for synthetic cell 600"
#> [1] "running downsamplePair for synthetic cell 601"
#> [1] "running downsamplePair for synthetic cell 602"
#> [1] "running downsamplePair for synthetic cell 603"
#> [1] "running downsamplePair for synthetic cell 604"
#> [1] "running downsamplePair for synthetic cell 605"
#> [1] "running downsamplePair for synthetic cell 606"
#> [1] "running downsamplePair for synthetic cell 607"
#> [1] "running downsamplePair for synthetic cell 608"
#> [1] "running downsamplePair for synthetic cell 609"
#> [1] "running downsamplePair for synthetic cell 610"
#> [1] "running downsamplePair for synthetic cell 611"
#> [1] "running downsamplePair for synthetic cell 612"
#> [1] "running downsamplePair for synthetic cell 613"
#> [1] "running downsamplePair for synthetic cell 614"
#> [1] "running downsamplePair for synthetic cell 615"
#> [1] "running downsamplePair for synthetic cell 616"
#> [1] "running downsamplePair for synthetic cell 617"
#> [1] "running downsamplePair for synthetic cell 618"
#> [1] "running downsamplePair for synthetic cell 619"
#> [1] "running downsamplePair for synthetic cell 620"
#> [1] "running downsamplePair for synthetic cell 621"
#> [1] "running downsamplePair for synthetic cell 622"
#> [1] "running downsamplePair for synthetic cell 623"
#> [1] "running downsamplePair for synthetic cell 624"
#> [1] "running downsamplePair for synthetic cell 625"
#> [1] "running downsamplePair for synthetic cell 626"
#> [1] "running downsamplePair for synthetic cell 627"
#> [1] "running downsamplePair for synthetic cell 628"
#> [1] "running downsamplePair for synthetic cell 629"
#> [1] "running downsamplePair for synthetic cell 630"
#> [1] "running downsamplePair for synthetic cell 631"
#> [1] "running downsamplePair for synthetic cell 632"
#> [1] "running downsamplePair for synthetic cell 633"
#> [1] "running downsamplePair for synthetic cell 634"
#> [1] "running downsamplePair for synthetic cell 635"
#> [1] "running downsamplePair for synthetic cell 636"
#> [1] "running downsamplePair for synthetic cell 637"
#> [1] "running downsamplePair for synthetic cell 638"
#> [1] "running downsamplePair for synthetic cell 639"
#> [1] "running downsamplePair for synthetic cell 640"
#> [1] "running downsamplePair for synthetic cell 641"
#> [1] "running downsamplePair for synthetic cell 642"
#> [1] "running downsamplePair for synthetic cell 643"
#> [1] "running downsamplePair for synthetic cell 644"
#> [1] "running downsamplePair for synthetic cell 645"
#> [1] "running downsamplePair for synthetic cell 646"
#> [1] "running downsamplePair for synthetic cell 647"
#> [1] "running downsamplePair for synthetic cell 648"
#> [1] "running downsamplePair for synthetic cell 649"
#> [1] "running downsamplePair for synthetic cell 650"
#> [1] "running downsamplePair for synthetic cell 651"
#> [1] "running downsamplePair for synthetic cell 652"
#> [1] "running downsamplePair for synthetic cell 653"
#> [1] "running downsamplePair for synthetic cell 654"
#> [1] "running downsamplePair for synthetic cell 655"
#> [1] "running downsamplePair for synthetic cell 656"
#> [1] "running downsamplePair for synthetic cell 657"
#> [1] "running downsamplePair for synthetic cell 658"
#> [1] "running downsamplePair for synthetic cell 659"
#> [1] "running downsamplePair for synthetic cell 660"
#> [1] "running downsamplePair for synthetic cell 661"
#> [1] "running downsamplePair for synthetic cell 662"
#> [1] "running downsamplePair for synthetic cell 663"
#> [1] "running downsamplePair for synthetic cell 664"
#> [1] "running downsamplePair for synthetic cell 665"
#> [1] "running downsamplePair for synthetic cell 666"
#> [1] "running downsamplePair for synthetic cell 667"
#> [1] "running downsamplePair for synthetic cell 668"
#> [1] "running downsamplePair for synthetic cell 669"
#> [1] "running downsamplePair for synthetic cell 670"
#> [1] "running downsamplePair for synthetic cell 671"
#> [1] "running downsamplePair for synthetic cell 672"
#> [1] "running downsamplePair for synthetic cell 673"
#> [1] "running downsamplePair for synthetic cell 674"
#> [1] "running downsamplePair for synthetic cell 675"
#> [1] "running downsamplePair for synthetic cell 676"
#> [1] "running downsamplePair for synthetic cell 677"
#> [1] "running downsamplePair for synthetic cell 678"
#> [1] "running downsamplePair for synthetic cell 679"
#> [1] "running downsamplePair for synthetic cell 680"
#> [1] "running downsamplePair for synthetic cell 681"
#> [1] "running downsamplePair for synthetic cell 682"
#> [1] "running downsamplePair for synthetic cell 683"
#> [1] "running downsamplePair for synthetic cell 684"
#> [1] "running downsamplePair for synthetic cell 685"
#> [1] "running downsamplePair for synthetic cell 686"
#> [1] "running downsamplePair for synthetic cell 687"
#> [1] "running downsamplePair for synthetic cell 688"
#> [1] "running downsamplePair for synthetic cell 689"
#> [1] "running downsamplePair for synthetic cell 690"
#> [1] "running downsamplePair for synthetic cell 691"
#> [1] "running downsamplePair for synthetic cell 692"
#> [1] "running downsamplePair for synthetic cell 693"
#> [1] "running downsamplePair for synthetic cell 694"
#> [1] "running downsamplePair for synthetic cell 695"
#> [1] "running downsamplePair for synthetic cell 696"
#> [1] "running downsamplePair for synthetic cell 697"
#> [1] "running downsamplePair for synthetic cell 698"
#> [1] "running downsamplePair for synthetic cell 699"
#> [1] "running downsamplePair for synthetic cell 700"
#> [1] "running downsamplePair for synthetic cell 701"
#> [1] "running downsamplePair for synthetic cell 702"
#> [1] "running downsamplePair for synthetic cell 703"
#> [1] "running downsamplePair for synthetic cell 704"
#> [1] "running downsamplePair for synthetic cell 705"
#> [1] "running downsamplePair for synthetic cell 706"
#> [1] "running downsamplePair for synthetic cell 707"
#> [1] "running downsamplePair for synthetic cell 708"
#> [1] "running downsamplePair for synthetic cell 709"
#> [1] "running downsamplePair for synthetic cell 710"
#> [1] "running downsamplePair for synthetic cell 711"
#> [1] "running downsamplePair for synthetic cell 712"
#> [1] "running downsamplePair for synthetic cell 713"
#> [1] "running downsamplePair for synthetic cell 714"
#> [1] "running downsamplePair for synthetic cell 715"
#> [1] "running downsamplePair for synthetic cell 716"
#> [1] "running downsamplePair for synthetic cell 717"
#> [1] "running downsamplePair for synthetic cell 718"
#> [1] "running downsamplePair for synthetic cell 719"
#> [1] "running downsamplePair for synthetic cell 720"
#> [1] "running downsamplePair for synthetic cell 721"
#> [1] "running downsamplePair for synthetic cell 722"
#> [1] "running downsamplePair for synthetic cell 723"
#> [1] "running downsamplePair for synthetic cell 724"
#> [1] "running downsamplePair for synthetic cell 725"
#> [1] "running downsamplePair for synthetic cell 726"
#> [1] "running downsamplePair for synthetic cell 727"
#> [1] "running downsamplePair for synthetic cell 728"
#> [1] "running downsamplePair for synthetic cell 729"
#> [1] "running downsamplePair for synthetic cell 730"
#> [1] "running downsamplePair for synthetic cell 731"
#> [1] "running downsamplePair for synthetic cell 732"
#> [1] "running downsamplePair for synthetic cell 733"
#> [1] "running downsamplePair for synthetic cell 734"
#> [1] "running downsamplePair for synthetic cell 735"
#> [1] "running downsamplePair for synthetic cell 736"
#> [1] "running downsamplePair for synthetic cell 737"
#> [1] "running downsamplePair for synthetic cell 738"
#> [1] "running downsamplePair for synthetic cell 739"
#> [1] "running downsamplePair for synthetic cell 740"
#> [1] "running downsamplePair for synthetic cell 741"
#> [1] "running downsamplePair for synthetic cell 742"
#> [1] "running downsamplePair for synthetic cell 743"
#> [1] "running downsamplePair for synthetic cell 744"
#> [1] "running downsamplePair for synthetic cell 745"
#> [1] "running downsamplePair for synthetic cell 746"
#> [1] "running downsamplePair for synthetic cell 747"
#> [1] "running downsamplePair for synthetic cell 748"
#> [1] "running downsamplePair for synthetic cell 749"
#> [1] "running downsamplePair for synthetic cell 750"
#> [1] "running downsamplePair for synthetic cell 751"
#> [1] "running downsamplePair for synthetic cell 752"
#> [1] "running downsamplePair for synthetic cell 753"
#> [1] "running downsamplePair for synthetic cell 754"
#> [1] "running downsamplePair for synthetic cell 755"
#> [1] "running downsamplePair for synthetic cell 756"
#> [1] "running downsamplePair for synthetic cell 757"
#> [1] "running downsamplePair for synthetic cell 758"
#> [1] "running downsamplePair for synthetic cell 759"
#> [1] "running downsamplePair for synthetic cell 760"
#> [1] "running downsamplePair for synthetic cell 761"
#> [1] "running downsamplePair for synthetic cell 762"
#> [1] "running downsamplePair for synthetic cell 763"
#> [1] "running downsamplePair for synthetic cell 764"
#> [1] "running downsamplePair for synthetic cell 765"
#> [1] "running downsamplePair for synthetic cell 766"
#> [1] "running downsamplePair for synthetic cell 767"
#> [1] "running downsamplePair for synthetic cell 768"
#> [1] "running downsamplePair for synthetic cell 769"
#> [1] "running downsamplePair for synthetic cell 770"
#> [1] "running downsamplePair for synthetic cell 771"
#> [1] "running downsamplePair for synthetic cell 772"
#> [1] "running downsamplePair for synthetic cell 773"
#> [1] "running downsamplePair for synthetic cell 774"
#> [1] "running downsamplePair for synthetic cell 775"
#> [1] "running downsamplePair for synthetic cell 776"
#> [1] "running downsamplePair for synthetic cell 777"
#> [1] "running downsamplePair for synthetic cell 778"
#> [1] "running downsamplePair for synthetic cell 779"
#> [1] "running downsamplePair for synthetic cell 780"
#> [1] "running downsamplePair for synthetic cell 781"
#> [1] "running downsamplePair for synthetic cell 782"
#> [1] "running downsamplePair for synthetic cell 783"
#> [1] "running downsamplePair for synthetic cell 784"
#> [1] "running downsamplePair for synthetic cell 785"
#> [1] "running downsamplePair for synthetic cell 786"
#> [1] "running downsamplePair for synthetic cell 787"
#> [1] "running downsamplePair for synthetic cell 788"
#> [1] "running downsamplePair for synthetic cell 789"
#> [1] "running downsamplePair for synthetic cell 790"
#> [1] "running downsamplePair for synthetic cell 791"
#> [1] "running downsamplePair for synthetic cell 792"
#> [1] "running downsamplePair for synthetic cell 793"
#> [1] "running downsamplePair for synthetic cell 794"
#> [1] "running downsamplePair for synthetic cell 795"
#> [1] "running downsamplePair for synthetic cell 796"
#> [1] "running downsamplePair for synthetic cell 797"
#> [1] "running downsamplePair for synthetic cell 798"
#> [1] "running downsamplePair for synthetic cell 799"
#> [1] "running downsamplePair for synthetic cell 800"
#> [1] "running downsamplePair for synthetic cell 801"
#> [1] "running downsamplePair for synthetic cell 802"
#> [1] "running downsamplePair for synthetic cell 803"
#> [1] "running downsamplePair for synthetic cell 804"
#> [1] "running downsamplePair for synthetic cell 805"
#> [1] "running downsamplePair for synthetic cell 806"
#> [1] "running downsamplePair for synthetic cell 807"
#> [1] "running downsamplePair for synthetic cell 808"
#> [1] "running downsamplePair for synthetic cell 809"
#> [1] "running downsamplePair for synthetic cell 810"
#> [1] "running downsamplePair for synthetic cell 811"
#> [1] "running downsamplePair for synthetic cell 812"
#> [1] "running downsamplePair for synthetic cell 813"
#> [1] "running downsamplePair for synthetic cell 814"
#> [1] "running downsamplePair for synthetic cell 815"
#> [1] "running downsamplePair for synthetic cell 816"
#> [1] "running downsamplePair for synthetic cell 817"
#> [1] "running downsamplePair for synthetic cell 818"
#> [1] "running downsamplePair for synthetic cell 819"
#> [1] "running downsamplePair for synthetic cell 820"
#> [1] "running downsamplePair for synthetic cell 821"
#> [1] "running downsamplePair for synthetic cell 822"
#> [1] "running downsamplePair for synthetic cell 823"
#> [1] "running downsamplePair for synthetic cell 824"
#> [1] "running downsamplePair for synthetic cell 825"
#> [1] "running downsamplePair for synthetic cell 826"
#> [1] "running downsamplePair for synthetic cell 827"
#> [1] "running downsamplePair for synthetic cell 828"
#> [1] "running downsamplePair for synthetic cell 829"
#> [1] "running downsamplePair for synthetic cell 830"
#> [1] "running downsamplePair for synthetic cell 831"
#> [1] "running downsamplePair for synthetic cell 832"
#> [1] "running downsamplePair for synthetic cell 833"
#> [1] "running downsamplePair for synthetic cell 834"
#> [1] "running downsamplePair for synthetic cell 835"
#> [1] "running downsamplePair for synthetic cell 836"
#> [1] "running downsamplePair for synthetic cell 837"
#> [1] "running downsamplePair for synthetic cell 838"
#> [1] "running downsamplePair for synthetic cell 839"
#> [1] "running downsamplePair for synthetic cell 840"
#> [1] "running downsamplePair for synthetic cell 841"
#> [1] "running downsamplePair for synthetic cell 842"
#> [1] "running downsamplePair for synthetic cell 843"
#> [1] "running downsamplePair for synthetic cell 844"
#> [1] "running downsamplePair for synthetic cell 845"
#> [1] "running downsamplePair for synthetic cell 846"
#> [1] "running downsamplePair for synthetic cell 847"
#> [1] "running downsamplePair for synthetic cell 848"
#> [1] "running downsamplePair for synthetic cell 849"
#> [1] "running downsamplePair for synthetic cell 850"
#> [1] "running downsamplePair for synthetic cell 851"
#> [1] "running downsamplePair for synthetic cell 852"
#> [1] "running downsamplePair for synthetic cell 853"
#> [1] "running downsamplePair for synthetic cell 854"
#> [1] "running downsamplePair for synthetic cell 855"
#> [1] "running downsamplePair for synthetic cell 856"
#> [1] "running downsamplePair for synthetic cell 857"
#> [1] "running downsamplePair for synthetic cell 858"
#> [1] "running downsamplePair for synthetic cell 859"
#> [1] "running downsamplePair for synthetic cell 860"
#> [1] "running downsamplePair for synthetic cell 861"
#> [1] "running downsamplePair for synthetic cell 862"
#> [1] "running downsamplePair for synthetic cell 863"
#> [1] "running downsamplePair for synthetic cell 864"
#> [1] "running downsamplePair for synthetic cell 865"
#> [1] "running downsamplePair for synthetic cell 866"
#> [1] "running downsamplePair for synthetic cell 867"
#> [1] "running downsamplePair for synthetic cell 868"
#> [1] "running downsamplePair for synthetic cell 869"
#> [1] "running downsamplePair for synthetic cell 870"
#> [1] "running downsamplePair for synthetic cell 871"
#> [1] "running downsamplePair for synthetic cell 872"
#> [1] "running downsamplePair for synthetic cell 873"
#> [1] "running downsamplePair for synthetic cell 874"
#> [1] "running downsamplePair for synthetic cell 875"
#> [1] "running downsamplePair for synthetic cell 876"
#> [1] "running downsamplePair for synthetic cell 877"
#> [1] "running downsamplePair for synthetic cell 878"
#> [1] "running downsamplePair for synthetic cell 879"
#> [1] "running downsamplePair for synthetic cell 880"
#> [1] "running downsamplePair for synthetic cell 881"
#> [1] "running downsamplePair for synthetic cell 882"
#> [1] "running downsamplePair for synthetic cell 883"
#> [1] "running downsamplePair for synthetic cell 884"
#> [1] "running downsamplePair for synthetic cell 885"
#> [1] "running downsamplePair for synthetic cell 886"
#> [1] "running downsamplePair for synthetic cell 887"
#> [1] "running downsamplePair for synthetic cell 888"
#> [1] "running downsamplePair for synthetic cell 889"
#> [1] "running downsamplePair for synthetic cell 890"
#> [1] "running downsamplePair for synthetic cell 891"
#> [1] "running downsamplePair for synthetic cell 892"
#> [1] "running downsamplePair for synthetic cell 893"
#> [1] "running downsamplePair for synthetic cell 894"
#> [1] "running downsamplePair for synthetic cell 895"
#> [1] "running downsamplePair for synthetic cell 896"
#> [1] "running downsamplePair for synthetic cell 897"
#> [1] "running downsamplePair for synthetic cell 898"
#> [1] "running downsamplePair for synthetic cell 899"
#> [1] "running downsamplePair for synthetic cell 900"
#> [1] "running downsamplePair for synthetic cell 901"
#> [1] "running downsamplePair for synthetic cell 902"
#> [1] "running downsamplePair for synthetic cell 903"
#> [1] "running downsamplePair for synthetic cell 904"
#> [1] "running downsamplePair for synthetic cell 905"
#> [1] "running downsamplePair for synthetic cell 906"
#> [1] "running downsamplePair for synthetic cell 907"
#> [1] "running downsamplePair for synthetic cell 908"
#> [1] "running downsamplePair for synthetic cell 909"
#> [1] "running downsamplePair for synthetic cell 910"
#> [1] "running downsamplePair for synthetic cell 911"
#> [1] "running downsamplePair for synthetic cell 912"
#> [1] "running downsamplePair for synthetic cell 913"
#> [1] "running downsamplePair for synthetic cell 914"
#> [1] "running downsamplePair for synthetic cell 915"
#> [1] "running downsamplePair for synthetic cell 916"
#> [1] "running downsamplePair for synthetic cell 917"
#> [1] "running downsamplePair for synthetic cell 918"
#> [1] "running downsamplePair for synthetic cell 919"
#> [1] "running downsamplePair for synthetic cell 920"
#> [1] "running downsamplePair for synthetic cell 921"
#> [1] "running downsamplePair for synthetic cell 922"
#> [1] "running downsamplePair for synthetic cell 923"
#> [1] "running downsamplePair for synthetic cell 924"
#> [1] "running downsamplePair for synthetic cell 925"
#> [1] "running downsamplePair for synthetic cell 926"
#> [1] "running downsamplePair for synthetic cell 927"
#> [1] "running downsamplePair for synthetic cell 928"
#> [1] "running downsamplePair for synthetic cell 929"
#> [1] "running downsamplePair for synthetic cell 930"
#> [1] "running downsamplePair for synthetic cell 931"
#> [1] "running downsamplePair for synthetic cell 932"
#> [1] "running downsamplePair for synthetic cell 933"
#> [1] "running downsamplePair for synthetic cell 934"
#> [1] "running downsamplePair for synthetic cell 935"
#> [1] "running downsamplePair for synthetic cell 936"
#> [1] "running downsamplePair for synthetic cell 937"
#> [1] "running downsamplePair for synthetic cell 938"
#> [1] "running downsamplePair for synthetic cell 939"
#> [1] "running downsamplePair for synthetic cell 940"
#> [1] "running downsamplePair for synthetic cell 941"
#> [1] "running downsamplePair for synthetic cell 942"
#> [1] "running downsamplePair for synthetic cell 943"
#> [1] "running downsamplePair for synthetic cell 944"
#> [1] "running downsamplePair for synthetic cell 945"
#> [1] "running downsamplePair for synthetic cell 946"
#> [1] "running downsamplePair for synthetic cell 947"
#> [1] "running downsamplePair for synthetic cell 948"
#> [1] "running downsamplePair for synthetic cell 949"
#> [1] "running downsamplePair for synthetic cell 950"
#> [1] "running downsamplePair for synthetic cell 951"
#> [1] "running downsamplePair for synthetic cell 952"
#> [1] "running downsamplePair for synthetic cell 953"
#> [1] "running downsamplePair for synthetic cell 954"
#> [1] "running downsamplePair for synthetic cell 955"
#> [1] "running downsamplePair for synthetic cell 956"
#> [1] "running downsamplePair for synthetic cell 957"
#> [1] "running downsamplePair for synthetic cell 958"
#> [1] "running downsamplePair for synthetic cell 959"
#> [1] "running downsamplePair for synthetic cell 960"
#> [1] "running downsamplePair for synthetic cell 961"
#> [1] "running downsamplePair for synthetic cell 962"
#> [1] "running downsamplePair for synthetic cell 963"
#> [1] "running downsamplePair for synthetic cell 964"
#> [1] "running downsamplePair for synthetic cell 965"
#> [1] "running downsamplePair for synthetic cell 966"
#> [1] "running downsamplePair for synthetic cell 967"
#> [1] "running downsamplePair for synthetic cell 968"
#> [1] "running downsamplePair for synthetic cell 969"
#> [1] "running downsamplePair for synthetic cell 970"
#> [1] "running downsamplePair for synthetic cell 971"
#> [1] "running downsamplePair for synthetic cell 972"
#> [1] "running downsamplePair for synthetic cell 973"
#> [1] "running downsamplePair for synthetic cell 974"
#> [1] "running downsamplePair for synthetic cell 975"
#> [1] "running downsamplePair for synthetic cell 976"
#> [1] "running downsamplePair for synthetic cell 977"
#> [1] "running downsamplePair for synthetic cell 978"
#> [1] "running downsamplePair for synthetic cell 979"
#> [1] "running downsamplePair for synthetic cell 980"
#> [1] "running downsamplePair for synthetic cell 981"
#> [1] "running downsamplePair for synthetic cell 982"
#> [1] "running downsamplePair for synthetic cell 983"
#> [1] "running downsamplePair for synthetic cell 984"
#> [1] "running downsamplePair for synthetic cell 985"
#> [1] "running downsamplePair for synthetic cell 986"
#> [1] "running downsamplePair for synthetic cell 987"
#> [1] "running downsamplePair for synthetic cell 988"
#> [1] "running downsamplePair for synthetic cell 989"
#> [1] "running downsamplePair for synthetic cell 990"
#> [1] "running downsamplePair for synthetic cell 991"
#> [1] "running downsamplePair for synthetic cell 992"
#> [1] "running downsamplePair for synthetic cell 993"
#> [1] "running downsamplePair for synthetic cell 994"
#> [1] "running downsamplePair for synthetic cell 995"
#> [1] "running downsamplePair for synthetic cell 996"
#> [1] "running downsamplePair for synthetic cell 997"
#> [1] "running downsamplePair for synthetic cell 998"
#> [1] "running downsamplePair for synthetic cell 999"
#> [1] "running downsamplePair for synthetic cell 1000"
#> [1] "running downsamplePair for synthetic cell 1001"
#> [1] "running downsamplePair for synthetic cell 1002"
#> [1] "running downsamplePair for synthetic cell 1003"
#> [1] "running downsamplePair for synthetic cell 1004"
#> [1] "running downsamplePair for synthetic cell 1005"
#> [1] "running downsamplePair for synthetic cell 1006"
#> [1] "running downsamplePair for synthetic cell 1007"
#> [1] "running downsamplePair for synthetic cell 1008"
#> [1] "running downsamplePair for synthetic cell 1009"
#> [1] "running downsamplePair for synthetic cell 1010"
#> [1] "running downsamplePair for synthetic cell 1011"
#> [1] "running downsamplePair for synthetic cell 1012"
#> [1] "running downsamplePair for synthetic cell 1013"
#> [1] "running downsamplePair for synthetic cell 1014"
#> [1] "running downsamplePair for synthetic cell 1015"
#> [1] "running downsamplePair for synthetic cell 1016"
#> [1] "running downsamplePair for synthetic cell 1017"
#> [1] "running downsamplePair for synthetic cell 1018"
#> [1] "running downsamplePair for synthetic cell 1019"
#> [1] "running downsamplePair for synthetic cell 1020"
#> [1] "running downsamplePair for synthetic cell 1021"
#> [1] "running downsamplePair for synthetic cell 1022"
#> [1] "running downsamplePair for synthetic cell 1023"
#> [1] "running downsamplePair for synthetic cell 1024"
#> [1] "running downsamplePair for synthetic cell 1025"
#> [1] "running downsamplePair for synthetic cell 1026"
#> [1] "running downsamplePair for synthetic cell 1027"
#> [1] "running downsamplePair for synthetic cell 1028"
#> [1] "running downsamplePair for synthetic cell 1029"
#> [1] "running downsamplePair for synthetic cell 1030"
#> [1] "running downsamplePair for synthetic cell 1031"
#> [1] "running downsamplePair for synthetic cell 1032"
#> [1] "running downsamplePair for synthetic cell 1033"
#> [1] "running downsamplePair for synthetic cell 1034"
#> [1] "running downsamplePair for synthetic cell 1035"
#> [1] "running downsamplePair for synthetic cell 1036"
#> [1] "running downsamplePair for synthetic cell 1037"
#> [1] "running downsamplePair for synthetic cell 1038"
#> [1] "running downsamplePair for synthetic cell 1039"
#> [1] "running downsamplePair for synthetic cell 1040"
#> [1] "running downsamplePair for synthetic cell 1041"
#> [1] "running downsamplePair for synthetic cell 1042"
#> [1] "running downsamplePair for synthetic cell 1043"
#> [1] "running downsamplePair for synthetic cell 1044"
#> [1] "running downsamplePair for synthetic cell 1045"
#> [1] "running downsamplePair for synthetic cell 1046"
#> [1] "running downsamplePair for synthetic cell 1047"
#> [1] "running downsamplePair for synthetic cell 1048"
#> [1] "running downsamplePair for synthetic cell 1049"
#> [1] "running downsamplePair for synthetic cell 1050"
#> [1] "running downsamplePair for synthetic cell 1051"
#> [1] "running downsamplePair for synthetic cell 1052"
#> [1] "running downsamplePair for synthetic cell 1053"
#> [1] "running downsamplePair for synthetic cell 1054"
#> [1] "running downsamplePair for synthetic cell 1055"
#> [1] "running downsamplePair for synthetic cell 1056"
#> [1] "running downsamplePair for synthetic cell 1057"
#> [1] "running downsamplePair for synthetic cell 1058"
#> [1] "running downsamplePair for synthetic cell 1059"
#> [1] "running downsamplePair for synthetic cell 1060"
#> [1] "running downsamplePair for synthetic cell 1061"
#> [1] "running downsamplePair for synthetic cell 1062"
#> [1] "running downsamplePair for synthetic cell 1063"
#> [1] "running downsamplePair for synthetic cell 1064"
#> [1] "running downsamplePair for synthetic cell 1065"
#> [1] "running downsamplePair for synthetic cell 1066"
#> [1] "running downsamplePair for synthetic cell 1067"
#> [1] "running downsamplePair for synthetic cell 1068"
#> [1] "running downsamplePair for synthetic cell 1069"
#> [1] "running downsamplePair for synthetic cell 1070"
#> [1] "running downsamplePair for synthetic cell 1071"
#> [1] "running downsamplePair for synthetic cell 1072"
#> [1] "running downsamplePair for synthetic cell 1073"
#> [1] "running downsamplePair for synthetic cell 1074"
#> [1] "running downsamplePair for synthetic cell 1075"
#> [1] "running downsamplePair for synthetic cell 1076"
#> [1] "running downsamplePair for synthetic cell 1077"
#> [1] "running downsamplePair for synthetic cell 1078"
#> [1] "running downsamplePair for synthetic cell 1079"
#> [1] "running downsamplePair for synthetic cell 1080"
#> [1] "running downsamplePair for synthetic cell 1081"
#> [1] "running downsamplePair for synthetic cell 1082"
#> [1] "running downsamplePair for synthetic cell 1083"
#> [1] "running downsamplePair for synthetic cell 1084"
#> [1] "running downsamplePair for synthetic cell 1085"
#> [1] "running downsamplePair for synthetic cell 1086"
#> [1] "running downsamplePair for synthetic cell 1087"
#> [1] "running downsamplePair for synthetic cell 1088"
#> [1] "running downsamplePair for synthetic cell 1089"
#> [1] "running downsamplePair for synthetic cell 1090"
#> [1] "running downsamplePair for synthetic cell 1091"
#> [1] "running downsamplePair for synthetic cell 1092"
#> [1] "running downsamplePair for synthetic cell 1093"
#> [1] "running downsamplePair for synthetic cell 1094"
#> [1] "running downsamplePair for synthetic cell 1095"
#> [1] "running downsamplePair for synthetic cell 1096"
#> [1] "running downsamplePair for synthetic cell 1097"
#> [1] "running downsamplePair for synthetic cell 1098"
#> [1] "running downsamplePair for synthetic cell 1099"
#> [1] "running downsamplePair for synthetic cell 1100"
#> [1] "running downsamplePair for synthetic cell 1101"
#> [1] "running downsamplePair for synthetic cell 1102"
#> [1] "running downsamplePair for synthetic cell 1103"
#> [1] "running downsamplePair for synthetic cell 1104"
#> [1] "running downsamplePair for synthetic cell 1105"
#> [1] "running downsamplePair for synthetic cell 1106"
#> [1] "running downsamplePair for synthetic cell 1107"
#> [1] "running downsamplePair for synthetic cell 1108"
#> [1] "running downsamplePair for synthetic cell 1109"
#> [1] "running downsamplePair for synthetic cell 1110"
#> [1] "running downsamplePair for synthetic cell 1111"
#> [1] "running downsamplePair for synthetic cell 1112"
#> [1] "running downsamplePair for synthetic cell 1113"
#> [1] "running downsamplePair for synthetic cell 1114"
#> [1] "running downsamplePair for synthetic cell 1115"
#> [1] "running downsamplePair for synthetic cell 1116"
#> [1] "running downsamplePair for synthetic cell 1117"
#> [1] "running downsamplePair for synthetic cell 1118"
#> [1] "running downsamplePair for synthetic cell 1119"
#> [1] "running downsamplePair for synthetic cell 1120"
#> [1] "running downsamplePair for synthetic cell 1121"
#> [1] "running downsamplePair for synthetic cell 1122"
#> [1] "running downsamplePair for synthetic cell 1123"
#> [1] "running downsamplePair for synthetic cell 1124"
#> [1] "running downsamplePair for synthetic cell 1125"
#> [1] "running downsamplePair for synthetic cell 1126"
#> [1] "running downsamplePair for synthetic cell 1127"
#> [1] "running downsamplePair for synthetic cell 1128"
#> [1] "running downsamplePair for synthetic cell 1129"
#> [1] "running downsamplePair for synthetic cell 1130"
#> [1] "running downsamplePair for synthetic cell 1131"
#> [1] "running downsamplePair for synthetic cell 1132"
#> [1] "running downsamplePair for synthetic cell 1133"
#> [1] "running downsamplePair for synthetic cell 1134"
#> [1] "running downsamplePair for synthetic cell 1135"
#> [1] "running downsamplePair for synthetic cell 1136"
#> [1] "running downsamplePair for synthetic cell 1137"
#> [1] "running downsamplePair for synthetic cell 1138"
#> [1] "running downsamplePair for synthetic cell 1139"
#> [1] "running downsamplePair for synthetic cell 1140"
#> [1] "running downsamplePair for synthetic cell 1141"
#> [1] "running downsamplePair for synthetic cell 1142"
#> [1] "running downsamplePair for synthetic cell 1143"
#> [1] "running downsamplePair for synthetic cell 1144"
#> [1] "running downsamplePair for synthetic cell 1145"
#> [1] "running downsamplePair for synthetic cell 1146"
#> [1] "running downsamplePair for synthetic cell 1147"
#> [1] "running downsamplePair for synthetic cell 1148"
#> [1] "running downsamplePair for synthetic cell 1149"
#> [1] "running downsamplePair for synthetic cell 1150"
#> [1] "running downsamplePair for synthetic cell 1151"
#> [1] "running downsamplePair for synthetic cell 1152"
#> [1] "running downsamplePair for synthetic cell 1153"
#> [1] "running downsamplePair for synthetic cell 1154"
#> [1] "running downsamplePair for synthetic cell 1155"
#> [1] "running downsamplePair for synthetic cell 1156"
#> [1] "running downsamplePair for synthetic cell 1157"
#> [1] "running downsamplePair for synthetic cell 1158"
#> [1] "running downsamplePair for synthetic cell 1159"
#> [1] "running downsamplePair for synthetic cell 1160"
#> [1] "running downsamplePair for synthetic cell 1161"
#> [1] "running downsamplePair for synthetic cell 1162"
#> [1] "running downsamplePair for synthetic cell 1163"
#> [1] "running downsamplePair for synthetic cell 1164"
#> [1] "running downsamplePair for synthetic cell 1165"
#> [1] "running downsamplePair for synthetic cell 1166"
#> [1] "running downsamplePair for synthetic cell 1167"
#> [1] "running downsamplePair for synthetic cell 1168"
#> [1] "running downsamplePair for synthetic cell 1169"
#> [1] "running downsamplePair for synthetic cell 1170"
#> [1] "running downsamplePair for synthetic cell 1171"
#> [1] "running downsamplePair for synthetic cell 1172"
#> [1] "running downsamplePair for synthetic cell 1173"
#> [1] "running downsamplePair for synthetic cell 1174"
#> [1] "running downsamplePair for synthetic cell 1175"
#> [1] "running downsamplePair for synthetic cell 1176"
#> [1] "running downsamplePair for synthetic cell 1177"
#> [1] "running downsamplePair for synthetic cell 1178"
#> [1] "running downsamplePair for synthetic cell 1179"
#> [1] "running downsamplePair for synthetic cell 1180"
#> [1] "running downsamplePair for synthetic cell 1181"
#> [1] "running downsamplePair for synthetic cell 1182"
#> [1] "running downsamplePair for synthetic cell 1183"
#> [1] "running downsamplePair for synthetic cell 1184"
#> [1] "running downsamplePair for synthetic cell 1185"
#> [1] "running downsamplePair for synthetic cell 1186"
#> [1] "running downsamplePair for synthetic cell 1187"
#> [1] "running downsamplePair for synthetic cell 1188"
#> [1] "running downsamplePair for synthetic cell 1189"
#> [1] "running downsamplePair for synthetic cell 1190"
#> [1] "running downsamplePair for synthetic cell 1191"
#> [1] "running downsamplePair for synthetic cell 1192"
#> [1] "running downsamplePair for synthetic cell 1193"
#> [1] "running downsamplePair for synthetic cell 1194"
#> [1] "running downsamplePair for synthetic cell 1195"
#> [1] "running downsamplePair for synthetic cell 1196"
#> [1] "running downsamplePair for synthetic cell 1197"
#> [1] "running downsamplePair for synthetic cell 1198"
#> [1] "running downsamplePair for synthetic cell 1199"
#> [1] "running downsamplePair for synthetic cell 1200"
#> [1] "running downsamplePair for synthetic cell 1201"
#> [1] "running downsamplePair for synthetic cell 1202"
#> [1] "running downsamplePair for synthetic cell 1203"
#> [1] "running downsamplePair for synthetic cell 1204"
#> [1] "running downsamplePair for synthetic cell 1205"
#> [1] "running downsamplePair for synthetic cell 1206"
#> [1] "running downsamplePair for synthetic cell 1207"
#> [1] "running downsamplePair for synthetic cell 1208"
#> [1] "running downsamplePair for synthetic cell 1209"
#> [1] "running downsamplePair for synthetic cell 1210"
#> [1] "running downsamplePair for synthetic cell 1211"
#> [1] "running downsamplePair for synthetic cell 1212"
#> [1] "running downsamplePair for synthetic cell 1213"
#> [1] "running downsamplePair for synthetic cell 1214"
#> [1] "running downsamplePair for synthetic cell 1215"
#> [1] "running downsamplePair for synthetic cell 1216"
#> [1] "running downsamplePair for synthetic cell 1217"
#> [1] "running downsamplePair for synthetic cell 1218"
#> [1] "running downsamplePair for synthetic cell 1219"
#> [1] "running downsamplePair for synthetic cell 1220"
#> [1] "running downsamplePair for synthetic cell 1221"
#> [1] "running downsamplePair for synthetic cell 1222"
#> [1] "running downsamplePair for synthetic cell 1223"
#> [1] "running downsamplePair for synthetic cell 1224"
#> [1] "running downsamplePair for synthetic cell 1225"
#> [1] "running downsamplePair for synthetic cell 1226"
#> [1] "running downsamplePair for synthetic cell 1227"
#> [1] "running downsamplePair for synthetic cell 1228"
#> [1] "running downsamplePair for synthetic cell 1229"
#> [1] "running downsamplePair for synthetic cell 1230"
#> [1] "running downsamplePair for synthetic cell 1231"
#> [1] "running downsamplePair for synthetic cell 1232"
#> [1] "running downsamplePair for synthetic cell 1233"
#> [1] "running downsamplePair for synthetic cell 1234"
#> [1] "running downsamplePair for synthetic cell 1235"
#> [1] "running downsamplePair for synthetic cell 1236"
#> [1] "running downsamplePair for synthetic cell 1237"
#> [1] "running downsamplePair for synthetic cell 1238"
#> [1] "running downsamplePair for synthetic cell 1239"
#> [1] "running downsamplePair for synthetic cell 1240"
#> [1] "running downsamplePair for synthetic cell 1241"
#> [1] "running downsamplePair for synthetic cell 1242"
#> [1] "running downsamplePair for synthetic cell 1243"
#> [1] "running downsamplePair for synthetic cell 1244"
#> [1] "running downsamplePair for synthetic cell 1245"
#> [1] "running downsamplePair for synthetic cell 1246"
#> [1] "running downsamplePair for synthetic cell 1247"
#> [1] "running downsamplePair for synthetic cell 1248"
#> [1] "running downsamplePair for synthetic cell 1249"
#> [1] "running downsamplePair for synthetic cell 1250"
#> [1] "running downsamplePair for synthetic cell 1251"
#> [1] "running downsamplePair for synthetic cell 1252"
#> [1] "running downsamplePair for synthetic cell 1253"
#> [1] "running downsamplePair for synthetic cell 1254"
#> [1] "running downsamplePair for synthetic cell 1255"
#> [1] "running downsamplePair for synthetic cell 1256"
#> [1] "running downsamplePair for synthetic cell 1257"
#> [1] "running downsamplePair for synthetic cell 1258"
#> [1] "running downsamplePair for synthetic cell 1259"
#> [1] "running downsamplePair for synthetic cell 1260"
#> [1] "running downsamplePair for synthetic cell 1261"
#> [1] "running downsamplePair for synthetic cell 1262"
#> [1] "running downsamplePair for synthetic cell 1263"
#> [1] "running downsamplePair for synthetic cell 1264"
#> [1] "running downsamplePair for synthetic cell 1265"
#> [1] "running downsamplePair for synthetic cell 1266"
#> [1] "running downsamplePair for synthetic cell 1267"
#> [1] "running downsamplePair for synthetic cell 1268"
#> [1] "running downsamplePair for synthetic cell 1269"
#> [1] "running downsamplePair for synthetic cell 1270"
#> [1] "running downsamplePair for synthetic cell 1271"
#> [1] "running downsamplePair for synthetic cell 1272"
#> [1] "running downsamplePair for synthetic cell 1273"
#> [1] "running downsamplePair for synthetic cell 1274"
#> [1] "running downsamplePair for synthetic cell 1275"
#> [1] "running downsamplePair for synthetic cell 1276"
#> [1] "running downsamplePair for synthetic cell 1277"
#> [1] "running downsamplePair for synthetic cell 1278"
#> [1] "running downsamplePair for synthetic cell 1279"
#> [1] "running downsamplePair for synthetic cell 1280"
#> [1] "running downsamplePair for synthetic cell 1281"
#> [1] "running downsamplePair for synthetic cell 1282"
#> [1] "running downsamplePair for synthetic cell 1283"
#> [1] "running downsamplePair for synthetic cell 1284"
#> [1] "running downsamplePair for synthetic cell 1285"
#> [1] "running downsamplePair for synthetic cell 1286"
#> [1] "running downsamplePair for synthetic cell 1287"
#> [1] "running downsamplePair for synthetic cell 1288"
#> [1] "running downsamplePair for synthetic cell 1289"
#> [1] "running downsamplePair for synthetic cell 1290"
#> [1] "running downsamplePair for synthetic cell 1291"
#> [1] "running downsamplePair for synthetic cell 1292"
#> [1] "running downsamplePair for synthetic cell 1293"
#> [1] "running downsamplePair for synthetic cell 1294"
#> [1] "running downsamplePair for synthetic cell 1295"
#> [1] "running downsamplePair for synthetic cell 1296"
#> [1] "running downsamplePair for synthetic cell 1297"
#> [1] "running downsamplePair for synthetic cell 1298"
#> [1] "running downsamplePair for synthetic cell 1299"
#> [1] "running downsamplePair for synthetic cell 1300"
#> [1] "running downsamplePair for synthetic cell 1301"
#> [1] "running downsamplePair for synthetic cell 1302"
#> [1] "running downsamplePair for synthetic cell 1303"
#> [1] "running downsamplePair for synthetic cell 1304"
#> [1] "running downsamplePair for synthetic cell 1305"
#> [1] "running downsamplePair for synthetic cell 1306"
#> [1] "running downsamplePair for synthetic cell 1307"
#> [1] "running downsamplePair for synthetic cell 1308"
#> [1] "running downsamplePair for synthetic cell 1309"
#> [1] "running downsamplePair for synthetic cell 1310"
#> [1] "running downsamplePair for synthetic cell 1311"
#> [1] "running downsamplePair for synthetic cell 1312"
#> [1] "running downsamplePair for synthetic cell 1313"
#> [1] "running downsamplePair for synthetic cell 1314"
#> [1] "running downsamplePair for synthetic cell 1315"
#> [1] "running downsamplePair for synthetic cell 1316"
#> [1] "running downsamplePair for synthetic cell 1317"
#> [1] "running downsamplePair for synthetic cell 1318"
#> [1] "running downsamplePair for synthetic cell 1319"
#> [1] "running downsamplePair for synthetic cell 1320"
#> [1] "running downsamplePair for synthetic cell 1321"
#> [1] "running downsamplePair for synthetic cell 1322"
#> [1] "running downsamplePair for synthetic cell 1323"
#> [1] "running downsamplePair for synthetic cell 1324"
#> [1] "running downsamplePair for synthetic cell 1325"
#> [1] "running downsamplePair for synthetic cell 1326"
#> [1] "running downsamplePair for synthetic cell 1327"
#> [1] "running downsamplePair for synthetic cell 1328"
#> [1] "running downsamplePair for synthetic cell 1329"
#> [1] "running downsamplePair for synthetic cell 1330"
#> [1] "running downsamplePair for synthetic cell 1331"
#> [1] "running downsamplePair for synthetic cell 1332"
#> [1] "running downsamplePair for synthetic cell 1333"
#> [1] "running downsamplePair for synthetic cell 1334"
#> [1] "running downsamplePair for synthetic cell 1335"
#> [1] "running downsamplePair for synthetic cell 1336"
#> [1] "running downsamplePair for synthetic cell 1337"
#> [1] "running downsamplePair for synthetic cell 1338"
#> [1] "running downsamplePair for synthetic cell 1339"
#> [1] "running downsamplePair for synthetic cell 1340"
#> [1] "running downsamplePair for synthetic cell 1341"
#> [1] "running downsamplePair for synthetic cell 1342"
#> [1] "running downsamplePair for synthetic cell 1343"
#> [1] "running downsamplePair for synthetic cell 1344"
#> [1] "running downsamplePair for synthetic cell 1345"
#> [1] "running downsamplePair for synthetic cell 1346"
#> [1] "running downsamplePair for synthetic cell 1347"
#> [1] "running downsamplePair for synthetic cell 1348"
#> [1] "running downsamplePair for synthetic cell 1349"
#> [1] "running downsamplePair for synthetic cell 1350"
#> [1] "running downsamplePair for synthetic cell 1351"
#> [1] "running downsamplePair for synthetic cell 1352"
#> [1] "running downsamplePair for synthetic cell 1353"
#> [1] "running downsamplePair for synthetic cell 1354"
#> [1] "running downsamplePair for synthetic cell 1355"
#> [1] "running downsamplePair for synthetic cell 1356"
#> [1] "running downsamplePair for synthetic cell 1357"
#> [1] "running downsamplePair for synthetic cell 1358"
#> [1] "running downsamplePair for synthetic cell 1359"
#> [1] "running downsamplePair for synthetic cell 1360"
#> [1] "running downsamplePair for synthetic cell 1361"
#> [1] "running downsamplePair for synthetic cell 1362"
#> [1] "running downsamplePair for synthetic cell 1363"
#> [1] "running downsamplePair for synthetic cell 1364"
#> [1] "running downsamplePair for synthetic cell 1365"
#> [1] "running downsamplePair for synthetic cell 1366"
#> [1] "running downsamplePair for synthetic cell 1367"
#> [1] "running downsamplePair for synthetic cell 1368"
#> [1] "running downsamplePair for synthetic cell 1369"
#> [1] "running downsamplePair for synthetic cell 1370"
#> [1] "running downsamplePair for synthetic cell 1371"
#> [1] "running downsamplePair for synthetic cell 1372"
#> [1] "running downsamplePair for synthetic cell 1373"
#> [1] "running downsamplePair for synthetic cell 1374"
#> [1] "running downsamplePair for synthetic cell 1375"
#> [1] "running downsamplePair for synthetic cell 1376"
#> [1] "running downsamplePair for synthetic cell 1377"
#> [1] "running downsamplePair for synthetic cell 1378"
#> [1] "running downsamplePair for synthetic cell 1379"
#> [1] "running downsamplePair for synthetic cell 1380"
#> [1] "running downsamplePair for synthetic cell 1381"
#> [1] "running downsamplePair for synthetic cell 1382"
#> [1] "running downsamplePair for synthetic cell 1383"
#> [1] "running downsamplePair for synthetic cell 1384"
#> [1] "running downsamplePair for synthetic cell 1385"
#> [1] "running downsamplePair for synthetic cell 1386"
#> [1] "running downsamplePair for synthetic cell 1387"
#> [1] "running downsamplePair for synthetic cell 1388"
#> [1] "running downsamplePair for synthetic cell 1389"
#> [1] "running downsamplePair for synthetic cell 1390"
#> [1] "running downsamplePair for synthetic cell 1391"
#> [1] "running downsamplePair for synthetic cell 1392"
#> [1] "running downsamplePair for synthetic cell 1393"
#> [1] "running downsamplePair for synthetic cell 1394"
#> [1] "running downsamplePair for synthetic cell 1395"
#> [1] "running downsamplePair for synthetic cell 1396"
#> [1] "running downsamplePair for synthetic cell 1397"
#> [1] "running downsamplePair for synthetic cell 1398"
#> [1] "running downsamplePair for synthetic cell 1399"
#> [1] "running downsamplePair for synthetic cell 1400"
#> [1] "running downsamplePair for synthetic cell 1401"
#> [1] "running downsamplePair for synthetic cell 1402"
#> [1] "running downsamplePair for synthetic cell 1403"
#> [1] "running downsamplePair for synthetic cell 1404"
#> [1] "running downsamplePair for synthetic cell 1405"
#> [1] "running downsamplePair for synthetic cell 1406"
#> [1] "running downsamplePair for synthetic cell 1407"
#> [1] "running downsamplePair for synthetic cell 1408"
#> [1] "running downsamplePair for synthetic cell 1409"
#> [1] "running downsamplePair for synthetic cell 1410"
#> [1] "running downsamplePair for synthetic cell 1411"
#> [1] "running downsamplePair for synthetic cell 1412"
#> [1] "running downsamplePair for synthetic cell 1413"
#> [1] "running downsamplePair for synthetic cell 1414"
#> [1] "running downsamplePair for synthetic cell 1415"
#> [1] "running downsamplePair for synthetic cell 1416"
#> [1] "running downsamplePair for synthetic cell 1417"
#> [1] "running downsamplePair for synthetic cell 1418"
#> [1] "running downsamplePair for synthetic cell 1419"
#> [1] "running downsamplePair for synthetic cell 1420"
#> [1] "running downsamplePair for synthetic cell 1421"
#> [1] "running downsamplePair for synthetic cell 1422"
#> [1] "running downsamplePair for synthetic cell 1423"
#> [1] "running downsamplePair for synthetic cell 1424"
#> [1] "running downsamplePair for synthetic cell 1425"
#> [1] "running downsamplePair for synthetic cell 1426"
#> [1] "running downsamplePair for synthetic cell 1427"
#> [1] "running downsamplePair for synthetic cell 1428"
#> [1] "running downsamplePair for synthetic cell 1429"
#> [1] "running downsamplePair for synthetic cell 1430"
#> [1] "running downsamplePair for synthetic cell 1431"
#> [1] "running downsamplePair for synthetic cell 1432"
#> [1] "running downsamplePair for synthetic cell 1433"
#> [1] "running downsamplePair for synthetic cell 1434"
#> [1] "running downsamplePair for synthetic cell 1435"
#> [1] "running downsamplePair for synthetic cell 1436"
#> [1] "running downsamplePair for synthetic cell 1437"
#> [1] "running downsamplePair for synthetic cell 1438"
#> [1] "running downsamplePair for synthetic cell 1439"
#> [1] "running downsamplePair for synthetic cell 1440"
#> [1] "running downsamplePair for synthetic cell 1441"
#> [1] "running downsamplePair for synthetic cell 1442"
#> [1] "running downsamplePair for synthetic cell 1443"
#> [1] "running downsamplePair for synthetic cell 1444"
#> [1] "running downsamplePair for synthetic cell 1445"
#> [1] "running downsamplePair for synthetic cell 1446"
#> [1] "running downsamplePair for synthetic cell 1447"
#> [1] "running downsamplePair for synthetic cell 1448"
#> [1] "running downsamplePair for synthetic cell 1449"
#> [1] "running downsamplePair for synthetic cell 1450"
#> [1] "running downsamplePair for synthetic cell 1451"
#> [1] "running downsamplePair for synthetic cell 1452"
#> [1] "running downsamplePair for synthetic cell 1453"
#> [1] "running downsamplePair for synthetic cell 1454"
#> [1] "running downsamplePair for synthetic cell 1455"
#> [1] "running downsamplePair for synthetic cell 1456"
#> [1] "running downsamplePair for synthetic cell 1457"
#> [1] "running downsamplePair for synthetic cell 1458"
#> [1] "running downsamplePair for synthetic cell 1459"
#> [1] "running downsamplePair for synthetic cell 1460"
#> [1] "running downsamplePair for synthetic cell 1461"
#> [1] "running downsamplePair for synthetic cell 1462"
#> [1] "running downsamplePair for synthetic cell 1463"
#> [1] "running downsamplePair for synthetic cell 1464"
#> [1] "running downsamplePair for synthetic cell 1465"
#> [1] "running downsamplePair for synthetic cell 1466"
#> [1] "running downsamplePair for synthetic cell 1467"
#> [1] "running downsamplePair for synthetic cell 1468"
#> [1] "running downsamplePair for synthetic cell 1469"
#> [1] "running downsamplePair for synthetic cell 1470"
#> [1] "running downsamplePair for synthetic cell 1471"
#> [1] "running downsamplePair for synthetic cell 1472"
#> [1] "running downsamplePair for synthetic cell 1473"
#> [1] "running downsamplePair for synthetic cell 1474"
#> [1] "running downsamplePair for synthetic cell 1475"
#> [1] "running downsamplePair for synthetic cell 1476"
#> [1] "running downsamplePair for synthetic cell 1477"
#> [1] "running downsamplePair for synthetic cell 1478"
#> [1] "running downsamplePair for synthetic cell 1479"
#> [1] "running downsamplePair for synthetic cell 1480"
#> [1] "running downsamplePair for synthetic cell 1481"
#> [1] "running downsamplePair for synthetic cell 1482"
#> [1] "running downsamplePair for synthetic cell 1483"
#> [1] "running downsamplePair for synthetic cell 1484"
#> [1] "running downsamplePair for synthetic cell 1485"
#> [1] "running downsamplePair for synthetic cell 1486"
#> [1] "running downsamplePair for synthetic cell 1487"
#> [1] "running downsamplePair for synthetic cell 1488"
#> [1] "running downsamplePair for synthetic cell 1489"
#> [1] "running downsamplePair for synthetic cell 1490"
#> [1] "running downsamplePair for synthetic cell 1491"
#> [1] "running downsamplePair for synthetic cell 1492"
#> [1] "running downsamplePair for synthetic cell 1493"
#> [1] "running downsamplePair for synthetic cell 1494"
#> [1] "running downsamplePair for synthetic cell 1495"
#> [1] "running downsamplePair for synthetic cell 1496"
#> [1] "running downsamplePair for synthetic cell 1497"
#> [1] "running downsamplePair for synthetic cell 1498"
#> [1] "running downsamplePair for synthetic cell 1499"
#> [1] "running downsamplePair for synthetic cell 1500"
#> [1] "running downsamplePair for synthetic cell 1501"
#> [1] "running downsamplePair for synthetic cell 1502"
#> [1] "running downsamplePair for synthetic cell 1503"
#> [1] "running downsamplePair for synthetic cell 1504"
#> [1] "running downsamplePair for synthetic cell 1505"
#> [1] "running downsamplePair for synthetic cell 1506"
#> [1] "running downsamplePair for synthetic cell 1507"
#> [1] "running downsamplePair for synthetic cell 1508"
#> [1] "running downsamplePair for synthetic cell 1509"
#> [1] "running downsamplePair for synthetic cell 1510"
#> [1] "running downsamplePair for synthetic cell 1511"
#> [1] "running downsamplePair for synthetic cell 1512"
#> [1] "running downsamplePair for synthetic cell 1513"
#> [1] "running downsamplePair for synthetic cell 1514"
#> [1] "running downsamplePair for synthetic cell 1515"
#> [1] "running downsamplePair for synthetic cell 1516"
#> [1] "running downsamplePair for synthetic cell 1517"
#> [1] "running downsamplePair for synthetic cell 1518"
#> [1] "running downsamplePair for synthetic cell 1519"
#> [1] "running downsamplePair for synthetic cell 1520"
#> [1] "running downsamplePair for synthetic cell 1521"
#> [1] "running downsamplePair for synthetic cell 1522"
#> [1] "running downsamplePair for synthetic cell 1523"
#> [1] "running downsamplePair for synthetic cell 1524"
#> [1] "running downsamplePair for synthetic cell 1525"
#> [1] "running downsamplePair for synthetic cell 1526"
#> [1] "running downsamplePair for synthetic cell 1527"
#> [1] "running downsamplePair for synthetic cell 1528"
#> [1] "running downsamplePair for synthetic cell 1529"
#> [1] "running downsamplePair for synthetic cell 1530"
#> [1] "running downsamplePair for synthetic cell 1531"
#> [1] "running downsamplePair for synthetic cell 1532"
#> [1] "running downsamplePair for synthetic cell 1533"
#> [1] "running downsamplePair for synthetic cell 1534"
#> [1] "running downsamplePair for synthetic cell 1535"
#> [1] "running downsamplePair for synthetic cell 1536"
#> [1] "running downsamplePair for synthetic cell 1537"
#> [1] "running downsamplePair for synthetic cell 1538"
#> [1] "running downsamplePair for synthetic cell 1539"
#> [1] "running downsamplePair for synthetic cell 1540"
#> [1] "running downsamplePair for synthetic cell 1541"
#> [1] "running downsamplePair for synthetic cell 1542"
#> [1] "running downsamplePair for synthetic cell 1543"
#> [1] "running downsamplePair for synthetic cell 1544"
#> [1] "running downsamplePair for synthetic cell 1545"
#> [1] "running downsamplePair for synthetic cell 1546"
#> [1] "running downsamplePair for synthetic cell 1547"
#> [1] "running downsamplePair for synthetic cell 1548"
#> [1] "running downsamplePair for synthetic cell 1549"
#> [1] "running downsamplePair for synthetic cell 1550"
#> [1] "running downsamplePair for synthetic cell 1551"
#> [1] "running downsamplePair for synthetic cell 1552"
#> [1] "running downsamplePair for synthetic cell 1553"
#> [1] "running downsamplePair for synthetic cell 1554"
#> [1] "running downsamplePair for synthetic cell 1555"
#> [1] "running downsamplePair for synthetic cell 1556"
#> [1] "running downsamplePair for synthetic cell 1557"
#> [1] "running downsamplePair for synthetic cell 1558"
#> [1] "running downsamplePair for synthetic cell 1559"
#> [1] "running downsamplePair for synthetic cell 1560"
#> [1] "running downsamplePair for synthetic cell 1561"
#> [1] "running downsamplePair for synthetic cell 1562"
#> [1] "running downsamplePair for synthetic cell 1563"
#> [1] "running downsamplePair for synthetic cell 1564"
#> [1] "running downsamplePair for synthetic cell 1565"
#> [1] "running downsamplePair for synthetic cell 1566"
#> [1] "running downsamplePair for synthetic cell 1567"
#> [1] "running downsamplePair for synthetic cell 1568"
#> [1] "running downsamplePair for synthetic cell 1569"
#> [1] "running downsamplePair for synthetic cell 1570"
#> [1] "running downsamplePair for synthetic cell 1571"
#> [1] "running downsamplePair for synthetic cell 1572"
#> [1] "running downsamplePair for synthetic cell 1573"
#> [1] "running downsamplePair for synthetic cell 1574"
#> [1] "running downsamplePair for synthetic cell 1575"
#> [1] "running downsamplePair for synthetic cell 1576"
#> [1] "running downsamplePair for synthetic cell 1577"
#> [1] "running downsamplePair for synthetic cell 1578"
#> [1] "running downsamplePair for synthetic cell 1579"
#> [1] "running downsamplePair for synthetic cell 1580"
#> [1] "running downsamplePair for synthetic cell 1581"
#> [1] "running downsamplePair for synthetic cell 1582"
#> [1] "running downsamplePair for synthetic cell 1583"
#> [1] "running downsamplePair for synthetic cell 1584"
#> [1] "running downsamplePair for synthetic cell 1585"
#> [1] "running downsamplePair for synthetic cell 1586"
#> [1] "running downsamplePair for synthetic cell 1587"
#> [1] "running downsamplePair for synthetic cell 1588"
#> [1] "running downsamplePair for synthetic cell 1589"
#> [1] "running downsamplePair for synthetic cell 1590"
#> [1] "running downsamplePair for synthetic cell 1591"
#> [1] "running downsamplePair for synthetic cell 1592"
#> [1] "running downsamplePair for synthetic cell 1593"
#> [1] "running downsamplePair for synthetic cell 1594"
#> [1] "running downsamplePair for synthetic cell 1595"
#> [1] "running downsamplePair for synthetic cell 1596"
#> [1] "running downsamplePair for synthetic cell 1597"
#> [1] "running downsamplePair for synthetic cell 1598"
#> [1] "running downsamplePair for synthetic cell 1599"
#> [1] "running downsamplePair for synthetic cell 1600"
#> [1] "running downsamplePair for synthetic cell 1601"
#> [1] "running downsamplePair for synthetic cell 1602"
#> [1] "running downsamplePair for synthetic cell 1603"
#> [1] "running downsamplePair for synthetic cell 1604"
#> [1] "running downsamplePair for synthetic cell 1605"
#> [1] "running downsamplePair for synthetic cell 1606"
#> [1] "running downsamplePair for synthetic cell 1607"
#> [1] "running downsamplePair for synthetic cell 1608"
#> [1] "running downsamplePair for synthetic cell 1609"
#> [1] "running downsamplePair for synthetic cell 1610"
#> [1] "running downsamplePair for synthetic cell 1611"
#> [1] "running downsamplePair for synthetic cell 1612"
#> [1] "running downsamplePair for synthetic cell 1613"
#> [1] "running downsamplePair for synthetic cell 1614"
#> [1] "running downsamplePair for synthetic cell 1615"
#> [1] "running downsamplePair for synthetic cell 1616"
#> [1] "running downsamplePair for synthetic cell 1617"
#> [1] "running downsamplePair for synthetic cell 1618"
#> [1] "running downsamplePair for synthetic cell 1619"
#> [1] "running downsamplePair for synthetic cell 1620"
#> [1] "running downsamplePair for synthetic cell 1621"
#> [1] "running downsamplePair for synthetic cell 1622"
#> [1] "running downsamplePair for synthetic cell 1623"
#> [1] "running downsamplePair for synthetic cell 1624"
#> [1] "running downsamplePair for synthetic cell 1625"
#> [1] "running downsamplePair for synthetic cell 1626"
#> [1] "running downsamplePair for synthetic cell 1627"
#> [1] "running downsamplePair for synthetic cell 1628"
#> [1] "running downsamplePair for synthetic cell 1629"
#> [1] "running downsamplePair for synthetic cell 1630"
#> [1] "running downsamplePair for synthetic cell 1631"
#> [1] "running downsamplePair for synthetic cell 1632"
#> [1] "running downsamplePair for synthetic cell 1633"
#> [1] "running downsamplePair for synthetic cell 1634"
#> [1] "running downsamplePair for synthetic cell 1635"
#> [1] "running downsamplePair for synthetic cell 1636"
#> [1] "running downsamplePair for synthetic cell 1637"
#> [1] "running downsamplePair for synthetic cell 1638"
#> [1] "running downsamplePair for synthetic cell 1639"
#> [1] "running downsamplePair for synthetic cell 1640"
#> [1] "running downsamplePair for synthetic cell 1641"
#> [1] "running downsamplePair for synthetic cell 1642"
#> [1] "running downsamplePair for synthetic cell 1643"
#> [1] "running downsamplePair for synthetic cell 1644"
#> [1] "running downsamplePair for synthetic cell 1645"
#> [1] "running downsamplePair for synthetic cell 1646"
#> [1] "running downsamplePair for synthetic cell 1647"
#> [1] "running downsamplePair for synthetic cell 1648"
#> [1] "running downsamplePair for synthetic cell 1649"
#> [1] "running downsamplePair for synthetic cell 1650"
#> [1] "running downsamplePair for synthetic cell 1651"
#> [1] "running downsamplePair for synthetic cell 1652"
#> [1] "running downsamplePair for synthetic cell 1653"
#> [1] "running downsamplePair for synthetic cell 1654"
#> [1] "running downsamplePair for synthetic cell 1655"
#> [1] "running downsamplePair for synthetic cell 1656"
#> [1] "running downsamplePair for synthetic cell 1657"
#> [1] "running downsamplePair for synthetic cell 1658"
#> [1] "running downsamplePair for synthetic cell 1659"
#> [1] "running downsamplePair for synthetic cell 1660"
#> [1] "running downsamplePair for synthetic cell 1661"
#> [1] "running downsamplePair for synthetic cell 1662"
#> [1] "running downsamplePair for synthetic cell 1663"
#> [1] "running downsamplePair for synthetic cell 1664"
#> [1] "running downsamplePair for synthetic cell 1665"
#> [1] "running downsamplePair for synthetic cell 1666"
#> [1] "running downsamplePair for synthetic cell 1667"
#> [1] "running downsamplePair for synthetic cell 1668"
#> [1] "running downsamplePair for synthetic cell 1669"
#> [1] "running downsamplePair for synthetic cell 1670"
#> [1] "running downsamplePair for synthetic cell 1671"
#> [1] "running downsamplePair for synthetic cell 1672"
#> [1] "running downsamplePair for synthetic cell 1673"
#> [1] "running downsamplePair for synthetic cell 1674"
#> [1] "running downsamplePair for synthetic cell 1675"
#> [1] "running downsamplePair for synthetic cell 1676"
#> [1] "running downsamplePair for synthetic cell 1677"
#> [1] "running downsamplePair for synthetic cell 1678"
#> [1] "running downsamplePair for synthetic cell 1679"
#> [1] "running downsamplePair for synthetic cell 1680"
#> [1] "running downsamplePair for synthetic cell 1681"
#> [1] "running downsamplePair for synthetic cell 1682"
#> [1] "running downsamplePair for synthetic cell 1683"
#> [1] "running downsamplePair for synthetic cell 1684"
#> [1] "running downsamplePair for synthetic cell 1685"
#> [1] "running downsamplePair for synthetic cell 1686"
#> [1] "running downsamplePair for synthetic cell 1687"
#> [1] "running downsamplePair for synthetic cell 1688"
#> [1] "running downsamplePair for synthetic cell 1689"
#> [1] "running downsamplePair for synthetic cell 1690"
#> [1] "running downsamplePair for synthetic cell 1691"
#> [1] "running downsamplePair for synthetic cell 1692"
#> [1] "running downsamplePair for synthetic cell 1693"
#> [1] "running downsamplePair for synthetic cell 1694"
#> [1] "running downsamplePair for synthetic cell 1695"
#> [1] "running downsamplePair for synthetic cell 1696"
#> [1] "running downsamplePair for synthetic cell 1697"
#> [1] "running downsamplePair for synthetic cell 1698"
#> [1] "running downsamplePair for synthetic cell 1699"
#> [1] "running downsamplePair for synthetic cell 1700"
#> [1] "running downsamplePair for synthetic cell 1701"
#> [1] "running downsamplePair for synthetic cell 1702"
#> [1] "running downsamplePair for synthetic cell 1703"
#> [1] "running downsamplePair for synthetic cell 1704"
#> [1] "running downsamplePair for synthetic cell 1705"
#> [1] "running downsamplePair for synthetic cell 1706"
#> [1] "running downsamplePair for synthetic cell 1707"
#> [1] "running downsamplePair for synthetic cell 1708"
#> [1] "running downsamplePair for synthetic cell 1709"
#> [1] "running downsamplePair for synthetic cell 1710"
#> [1] "running downsamplePair for synthetic cell 1711"
#> [1] "running downsamplePair for synthetic cell 1712"
#> [1] "running downsamplePair for synthetic cell 1713"
#> [1] "running downsamplePair for synthetic cell 1714"
#> [1] "running downsamplePair for synthetic cell 1715"
#> [1] "running downsamplePair for synthetic cell 1716"
#> [1] "running downsamplePair for synthetic cell 1717"
#> [1] "running downsamplePair for synthetic cell 1718"
#> [1] "running downsamplePair for synthetic cell 1719"
#> [1] "running downsamplePair for synthetic cell 1720"
#> [1] "running downsamplePair for synthetic cell 1721"
#> [1] "running downsamplePair for synthetic cell 1722"
#> [1] "running downsamplePair for synthetic cell 1723"
#> [1] "running downsamplePair for synthetic cell 1724"
#> [1] "running downsamplePair for synthetic cell 1725"
#> [1] "running downsamplePair for synthetic cell 1726"
#> [1] "running downsamplePair for synthetic cell 1727"
#> [1] "running downsamplePair for synthetic cell 1728"
#> [1] "running downsamplePair for synthetic cell 1729"
#> [1] "running downsamplePair for synthetic cell 1730"
#> [1] "running downsamplePair for synthetic cell 1731"
#> [1] "running downsamplePair for synthetic cell 1732"
#> [1] "running downsamplePair for synthetic cell 1733"
#> [1] "running downsamplePair for synthetic cell 1734"
#> [1] "running downsamplePair for synthetic cell 1735"
#> [1] "running downsamplePair for synthetic cell 1736"
#> [1] "running downsamplePair for synthetic cell 1737"
#> [1] "running downsamplePair for synthetic cell 1738"
#> [1] "running downsamplePair for synthetic cell 1739"
#> [1] "running downsamplePair for synthetic cell 1740"
#> [1] "running downsamplePair for synthetic cell 1741"
#> [1] "running downsamplePair for synthetic cell 1742"
#> [1] "running downsamplePair for synthetic cell 1743"
#> [1] "running downsamplePair for synthetic cell 1744"
#> [1] "running downsamplePair for synthetic cell 1745"
#> [1] "running downsamplePair for synthetic cell 1746"
#> [1] "running downsamplePair for synthetic cell 1747"
#> [1] "running downsamplePair for synthetic cell 1748"
#> [1] "running downsamplePair for synthetic cell 1749"
#> [1] "running downsamplePair for synthetic cell 1750"
#> [1] "running downsamplePair for synthetic cell 1751"
#> [1] "running downsamplePair for synthetic cell 1752"
#> [1] "running downsamplePair for synthetic cell 1753"
#> [1] "running downsamplePair for synthetic cell 1754"
#> [1] "running downsamplePair for synthetic cell 1755"
#> [1] "running downsamplePair for synthetic cell 1756"
#> [1] "running downsamplePair for synthetic cell 1757"
#> [1] "running downsamplePair for synthetic cell 1758"
#> [1] "running downsamplePair for synthetic cell 1759"
#> [1] "running downsamplePair for synthetic cell 1760"
#> [1] "running downsamplePair for synthetic cell 1761"
#> [1] "running downsamplePair for synthetic cell 1762"
#> [1] "running downsamplePair for synthetic cell 1763"
#> [1] "running downsamplePair for synthetic cell 1764"
#> [1] "running downsamplePair for synthetic cell 1765"
#> [1] "running downsamplePair for synthetic cell 1766"
#> [1] "running downsamplePair for synthetic cell 1767"
#> [1] "running downsamplePair for synthetic cell 1768"
#> [1] "running downsamplePair for synthetic cell 1769"
#> [1] "running downsamplePair for synthetic cell 1770"
#> [1] "running downsamplePair for synthetic cell 1771"
#> [1] "running downsamplePair for synthetic cell 1772"
#> [1] "running downsamplePair for synthetic cell 1773"
#> [1] "running downsamplePair for synthetic cell 1774"
#> [1] "running downsamplePair for synthetic cell 1775"
#> [1] "running downsamplePair for synthetic cell 1776"
#> [1] "running downsamplePair for synthetic cell 1777"
#> [1] "running downsamplePair for synthetic cell 1778"
#> [1] "running downsamplePair for synthetic cell 1779"
#> [1] "running downsamplePair for synthetic cell 1780"
#> [1] "running downsamplePair for synthetic cell 1781"
#> [1] "running downsamplePair for synthetic cell 1782"
#> [1] "running downsamplePair for synthetic cell 1783"
#> [1] "running downsamplePair for synthetic cell 1784"
#> [1] "running downsamplePair for synthetic cell 1785"
#> [1] "running downsamplePair for synthetic cell 1786"
#> [1] "running downsamplePair for synthetic cell 1787"
#> [1] "running downsamplePair for synthetic cell 1788"
#> [1] "running downsamplePair for synthetic cell 1789"
#> [1] "running downsamplePair for synthetic cell 1790"
#> [1] "running downsamplePair for synthetic cell 1791"
#> [1] "running downsamplePair for synthetic cell 1792"
#> [1] "running downsamplePair for synthetic cell 1793"
#> [1] "running downsamplePair for synthetic cell 1794"
#> [1] "running downsamplePair for synthetic cell 1795"
#> [1] "running downsamplePair for synthetic cell 1796"
#> [1] "running downsamplePair for synthetic cell 1797"
#> [1] "running downsamplePair for synthetic cell 1798"
#> [1] "running downsamplePair for synthetic cell 1799"
#> [1] "running downsamplePair for synthetic cell 1800"
#> [1] "running downsamplePair for synthetic cell 1801"
#> [1] "running downsamplePair for synthetic cell 1802"
#> [1] "running downsamplePair for synthetic cell 1803"
#> [1] "running downsamplePair for synthetic cell 1804"
#> [1] "running downsamplePair for synthetic cell 1805"
#> [1] "running downsamplePair for synthetic cell 1806"
#> [1] "running downsamplePair for synthetic cell 1807"
#> [1] "running downsamplePair for synthetic cell 1808"
#> [1] "running downsamplePair for synthetic cell 1809"
#> [1] "running downsamplePair for synthetic cell 1810"
#> [1] "running downsamplePair for synthetic cell 1811"
#> [1] "running downsamplePair for synthetic cell 1812"
#> [1] "running downsamplePair for synthetic cell 1813"
#> [1] "running downsamplePair for synthetic cell 1814"
#> [1] "running downsamplePair for synthetic cell 1815"
#> [1] "running downsamplePair for synthetic cell 1816"
#> [1] "running downsamplePair for synthetic cell 1817"
#> [1] "running downsamplePair for synthetic cell 1818"
#> [1] "running downsamplePair for synthetic cell 1819"
#> [1] "running downsamplePair for synthetic cell 1820"
#> [1] "running downsamplePair for synthetic cell 1821"
#> [1] "running downsamplePair for synthetic cell 1822"
#> [1] "running downsamplePair for synthetic cell 1823"
#> [1] "running downsamplePair for synthetic cell 1824"
#> [1] "running downsamplePair for synthetic cell 1825"
#> [1] "running downsamplePair for synthetic cell 1826"
#> [1] "running downsamplePair for synthetic cell 1827"
#> [1] "running downsamplePair for synthetic cell 1828"
#> [1] "running downsamplePair for synthetic cell 1829"
#> [1] "running downsamplePair for synthetic cell 1830"
#> [1] "running downsamplePair for synthetic cell 1831"
#> [1] "running downsamplePair for synthetic cell 1832"
#> [1] "running downsamplePair for synthetic cell 1833"
#> [1] "running downsamplePair for synthetic cell 1834"
#> [1] "running downsamplePair for synthetic cell 1835"
#> [1] "running downsamplePair for synthetic cell 1836"
#> [1] "running downsamplePair for synthetic cell 1837"
#> [1] "running downsamplePair for synthetic cell 1838"
#> [1] "running downsamplePair for synthetic cell 1839"
#> [1] "running downsamplePair for synthetic cell 1840"
#> [1] "running downsamplePair for synthetic cell 1841"
#> [1] "running downsamplePair for synthetic cell 1842"
#> [1] "running downsamplePair for synthetic cell 1843"
#> [1] "running downsamplePair for synthetic cell 1844"
#> [1] "running downsamplePair for synthetic cell 1845"
#> [1] "running downsamplePair for synthetic cell 1846"
#> [1] "running downsamplePair for synthetic cell 1847"
#> [1] "running downsamplePair for synthetic cell 1848"
#> [1] "running downsamplePair for synthetic cell 1849"
#> [1] "running downsamplePair for synthetic cell 1850"
#> [1] "running downsamplePair for synthetic cell 1851"
#> [1] "running downsamplePair for synthetic cell 1852"
#> [1] "running downsamplePair for synthetic cell 1853"
#> [1] "running downsamplePair for synthetic cell 1854"
#> [1] "running downsamplePair for synthetic cell 1855"
#> [1] "running downsamplePair for synthetic cell 1856"
#> [1] "running downsamplePair for synthetic cell 1857"
#> [1] "running downsamplePair for synthetic cell 1858"
#> [1] "running downsamplePair for synthetic cell 1859"
#> [1] "running downsamplePair for synthetic cell 1860"
#> [1] "running downsamplePair for synthetic cell 1861"
#> [1] "running downsamplePair for synthetic cell 1862"
#> [1] "running downsamplePair for synthetic cell 1863"
#> [1] "running downsamplePair for synthetic cell 1864"
#> [1] "running downsamplePair for synthetic cell 1865"
#> [1] "running downsamplePair for synthetic cell 1866"
#> [1] "running downsamplePair for synthetic cell 1867"
#> [1] "running downsamplePair for synthetic cell 1868"
#> [1] "running downsamplePair for synthetic cell 1869"
#> [1] "running downsamplePair for synthetic cell 1870"
#> [1] "running downsamplePair for synthetic cell 1871"
#> [1] "running downsamplePair for synthetic cell 1872"
#> [1] "running downsamplePair for synthetic cell 1873"
#> [1] "running downsamplePair for synthetic cell 1874"
#> [1] "running downsamplePair for synthetic cell 1875"
#> [1] "running downsamplePair for synthetic cell 1876"
#> [1] "running downsamplePair for synthetic cell 1877"
#> [1] "running downsamplePair for synthetic cell 1878"
#> [1] "running downsamplePair for synthetic cell 1879"
#> [1] "running downsamplePair for synthetic cell 1880"
#> [1] "running downsamplePair for synthetic cell 1881"
#> [1] "running downsamplePair for synthetic cell 1882"
#> [1] "running downsamplePair for synthetic cell 1883"
#> [1] "running downsamplePair for synthetic cell 1884"
#> [1] "running downsamplePair for synthetic cell 1885"
#> [1] "running downsamplePair for synthetic cell 1886"
#> [1] "running downsamplePair for synthetic cell 1887"
#> [1] "running downsamplePair for synthetic cell 1888"
#> [1] "running downsamplePair for synthetic cell 1889"
#> [1] "running downsamplePair for synthetic cell 1890"
#> [1] "running downsamplePair for synthetic cell 1891"
#> [1] "running downsamplePair for synthetic cell 1892"
#> [1] "running downsamplePair for synthetic cell 1893"
#> [1] "running downsamplePair for synthetic cell 1894"
#> [1] "running downsamplePair for synthetic cell 1895"
#> [1] "running downsamplePair for synthetic cell 1896"
#> [1] "running downsamplePair for synthetic cell 1897"
#> [1] "running downsamplePair for synthetic cell 1898"
#> [1] "running downsamplePair for synthetic cell 1899"
#> [1] "running downsamplePair for synthetic cell 1900"
#> [1] "running downsamplePair for synthetic cell 1901"
#> [1] "running downsamplePair for synthetic cell 1902"
#> [1] "running downsamplePair for synthetic cell 1903"
#> [1] "running downsamplePair for synthetic cell 1904"
#> [1] "running downsamplePair for synthetic cell 1905"
#> [1] "running downsamplePair for synthetic cell 1906"
#> [1] "running downsamplePair for synthetic cell 1907"
#> [1] "running downsamplePair for synthetic cell 1908"
#> [1] "running downsamplePair for synthetic cell 1909"
#> [1] "running downsamplePair for synthetic cell 1910"
#> [1] "running downsamplePair for synthetic cell 1911"
#> [1] "running downsamplePair for synthetic cell 1912"
#> [1] "running downsamplePair for synthetic cell 1913"
#> [1] "running downsamplePair for synthetic cell 1914"
#> [1] "running downsamplePair for synthetic cell 1915"
#> [1] "running downsamplePair for synthetic cell 1916"
#> [1] "running downsamplePair for synthetic cell 1917"
#> [1] "running downsamplePair for synthetic cell 1918"
#> [1] "running downsamplePair for synthetic cell 1919"
#> [1] "running downsamplePair for synthetic cell 1920"
#> [1] "running downsamplePair for synthetic cell 1921"
#> [1] "running downsamplePair for synthetic cell 1922"
#> [1] "running downsamplePair for synthetic cell 1923"
#> [1] "running downsamplePair for synthetic cell 1924"
#> [1] "running downsamplePair for synthetic cell 1925"
#> [1] "running downsamplePair for synthetic cell 1926"
#> [1] "running downsamplePair for synthetic cell 1927"
#> [1] "running downsamplePair for synthetic cell 1928"
#> [1] "running downsamplePair for synthetic cell 1929"
#> [1] "running downsamplePair for synthetic cell 1930"
#> [1] "running downsamplePair for synthetic cell 1931"
#> [1] "running downsamplePair for synthetic cell 1932"
#> [1] "running downsamplePair for synthetic cell 1933"
#> [1] "running downsamplePair for synthetic cell 1934"
#> [1] "running downsamplePair for synthetic cell 1935"
#> [1] "running downsamplePair for synthetic cell 1936"
#> [1] "running downsamplePair for synthetic cell 1937"
#> [1] "running downsamplePair for synthetic cell 1938"
#> [1] "running downsamplePair for synthetic cell 1939"
#> [1] "running downsamplePair for synthetic cell 1940"
#> [1] "running downsamplePair for synthetic cell 1941"
#> [1] "running downsamplePair for synthetic cell 1942"
#> [1] "running downsamplePair for synthetic cell 1943"
#> [1] "running downsamplePair for synthetic cell 1944"
#> [1] "running downsamplePair for synthetic cell 1945"
#> [1] "running downsamplePair for synthetic cell 1946"
#> [1] "running downsamplePair for synthetic cell 1947"
#> [1] "running downsamplePair for synthetic cell 1948"
#> [1] "running downsamplePair for synthetic cell 1949"
#> [1] "running downsamplePair for synthetic cell 1950"
#> [1] "running downsamplePair for synthetic cell 1951"
#> [1] "running downsamplePair for synthetic cell 1952"
#> [1] "running downsamplePair for synthetic cell 1953"
#> [1] "running downsamplePair for synthetic cell 1954"
#> [1] "running downsamplePair for synthetic cell 1955"
#> [1] "running downsamplePair for synthetic cell 1956"
#> [1] "running downsamplePair for synthetic cell 1957"
#> [1] "running downsamplePair for synthetic cell 1958"
#> [1] "running downsamplePair for synthetic cell 1959"
#> [1] "running downsamplePair for synthetic cell 1960"
#> [1] "running downsamplePair for synthetic cell 1961"
#> [1] "running downsamplePair for synthetic cell 1962"
#> [1] "running downsamplePair for synthetic cell 1963"
#> [1] "running downsamplePair for synthetic cell 1964"
#> [1] "running downsamplePair for synthetic cell 1965"
#> [1] "running downsamplePair for synthetic cell 1966"
#> [1] "running downsamplePair for synthetic cell 1967"
#> [1] "running downsamplePair for synthetic cell 1968"
#> [1] "running downsamplePair for synthetic cell 1969"
#> [1] "running downsamplePair for synthetic cell 1970"
#> [1] "running downsamplePair for synthetic cell 1971"
#> [1] "running downsamplePair for synthetic cell 1972"
#> [1] "running downsamplePair for synthetic cell 1973"
#> [1] "running downsamplePair for synthetic cell 1974"
#> [1] "running downsamplePair for synthetic cell 1975"
#> [1] "running downsamplePair for synthetic cell 1976"
#> [1] "running downsamplePair for synthetic cell 1977"
#> [1] "running downsamplePair for synthetic cell 1978"
#> [1] "running downsamplePair for synthetic cell 1979"
#> [1] "running downsamplePair for synthetic cell 1980"
#> [1] "running downsamplePair for synthetic cell 1981"
#> [1] "running downsamplePair for synthetic cell 1982"
#> [1] "running downsamplePair for synthetic cell 1983"
#> [1] "running downsamplePair for synthetic cell 1984"
#> [1] "running downsamplePair for synthetic cell 1985"
#> [1] "running downsamplePair for synthetic cell 1986"
#> [1] "running downsamplePair for synthetic cell 1987"
#> [1] "running downsamplePair for synthetic cell 1988"
#> [1] "running downsamplePair for synthetic cell 1989"
#> [1] "running downsamplePair for synthetic cell 1990"
#> [1] "running downsamplePair for synthetic cell 1991"
#> [1] "running downsamplePair for synthetic cell 1992"
#> [1] "running downsamplePair for synthetic cell 1993"
#> [1] "running downsamplePair for synthetic cell 1994"
#> [1] "running downsamplePair for synthetic cell 1995"
#> [1] "running downsamplePair for synthetic cell 1996"
#> [1] "running downsamplePair for synthetic cell 1997"
#> [1] "running downsamplePair for synthetic cell 1998"
#> [1] "running downsamplePair for synthetic cell 1999"
#> [1] "running downsamplePair for synthetic cell 2000"
#> [1] "running downsamplePair for synthetic cell 2001"
#> [1] "running downsamplePair for synthetic cell 2002"
#> [1] "running downsamplePair for synthetic cell 2003"
#> [1] "running downsamplePair for synthetic cell 2004"
#> [1] "running downsamplePair for synthetic cell 2005"
#> [1] "running downsamplePair for synthetic cell 2006"
#> [1] "running downsamplePair for synthetic cell 2007"
#> [1] "running downsamplePair for synthetic cell 2008"
#> [1] "running downsamplePair for synthetic cell 2009"
#> [1] "running downsamplePair for synthetic cell 2010"
#> [1] "running downsamplePair for synthetic cell 2011"
#> [1] "running downsamplePair for synthetic cell 2012"
#> [1] "running downsamplePair for synthetic cell 2013"
#> [1] "running downsamplePair for synthetic cell 2014"
#> [1] "running downsamplePair for synthetic cell 2015"
#> [1] "running downsamplePair for synthetic cell 2016"
#> [1] "running downsamplePair for synthetic cell 2017"
#> [1] "running downsamplePair for synthetic cell 2018"
#> [1] "running downsamplePair for synthetic cell 2019"
#> [1] "running downsamplePair for synthetic cell 2020"
#> [1] "running downsamplePair for synthetic cell 2021"
#> [1] "running downsamplePair for synthetic cell 2022"
#> [1] "running downsamplePair for synthetic cell 2023"
#> [1] "running downsamplePair for synthetic cell 2024"
#> [1] "running downsamplePair for synthetic cell 2025"
#> [1] "running downsamplePair for synthetic cell 2026"
#> [1] "running downsamplePair for synthetic cell 2027"
#> [1] "running downsamplePair for synthetic cell 2028"
#> [1] "running downsamplePair for synthetic cell 2029"
#> [1] "running downsamplePair for synthetic cell 2030"
#> [1] "running downsamplePair for synthetic cell 2031"
#> [1] "running downsamplePair for synthetic cell 2032"
#> [1] "running downsamplePair for synthetic cell 2033"
#> [1] "running downsamplePair for synthetic cell 2034"
#> [1] "running downsamplePair for synthetic cell 2035"
#> [1] "running downsamplePair for synthetic cell 2036"
#> [1] "running downsamplePair for synthetic cell 2037"
#> [1] "running downsamplePair for synthetic cell 2038"
#> [1] "running downsamplePair for synthetic cell 2039"
#> [1] "running downsamplePair for synthetic cell 2040"
#> [1] "running downsamplePair for synthetic cell 2041"
#> [1] "running downsamplePair for synthetic cell 2042"
#> [1] "running downsamplePair for synthetic cell 2043"
#> [1] "running downsamplePair for synthetic cell 2044"
#> [1] "running downsamplePair for synthetic cell 2045"
#> [1] "running downsamplePair for synthetic cell 2046"
#> [1] "running downsamplePair for synthetic cell 2047"
#> [1] "running downsamplePair for synthetic cell 2048"
#> [1] "running downsamplePair for synthetic cell 2049"
#> [1] "running downsamplePair for synthetic cell 2050"
#> [1] "running downsamplePair for synthetic cell 2051"
#> [1] "running downsamplePair for synthetic cell 2052"
#> [1] "running downsamplePair for synthetic cell 2053"
#> [1] "running downsamplePair for synthetic cell 2054"
#> [1] "running downsamplePair for synthetic cell 2055"
#> [1] "running downsamplePair for synthetic cell 2056"
#> [1] "running downsamplePair for synthetic cell 2057"
#> [1] "running downsamplePair for synthetic cell 2058"
#> [1] "running downsamplePair for synthetic cell 2059"
#> [1] "running downsamplePair for synthetic cell 2060"
#> [1] "running downsamplePair for synthetic cell 2061"
#> [1] "running downsamplePair for synthetic cell 2062"
#> [1] "running downsamplePair for synthetic cell 2063"
#> [1] "running downsamplePair for synthetic cell 2064"
#> [1] "running downsamplePair for synthetic cell 2065"
#> [1] "running downsamplePair for synthetic cell 2066"
#> [1] "running downsamplePair for synthetic cell 2067"
#> [1] "running downsamplePair for synthetic cell 2068"
#> [1] "running downsamplePair for synthetic cell 2069"
#> [1] "running downsamplePair for synthetic cell 2070"
#> [1] "running downsamplePair for synthetic cell 2071"
#> [1] "running downsamplePair for synthetic cell 2072"
#> [1] "running downsamplePair for synthetic cell 2073"
#> [1] "running downsamplePair for synthetic cell 2074"
#> [1] "running downsamplePair for synthetic cell 2075"
#> [1] "running downsamplePair for synthetic cell 2076"
#> [1] "running downsamplePair for synthetic cell 2077"
#> [1] "running downsamplePair for synthetic cell 2078"
#> [1] "running downsamplePair for synthetic cell 2079"
#> [1] "running downsamplePair for synthetic cell 2080"
#> [1] "running downsamplePair for synthetic cell 2081"
#> [1] "running downsamplePair for synthetic cell 2082"
#> [1] "running downsamplePair for synthetic cell 2083"
#> [1] "running downsamplePair for synthetic cell 2084"
#> [1] "running downsamplePair for synthetic cell 2085"
#> [1] "running downsamplePair for synthetic cell 2086"
#> [1] "running downsamplePair for synthetic cell 2087"
#> [1] "running downsamplePair for synthetic cell 2088"
#> [1] "running downsamplePair for synthetic cell 2089"
#> [1] "running downsamplePair for synthetic cell 2090"
#> [1] "running downsamplePair for synthetic cell 2091"
#> [1] "running downsamplePair for synthetic cell 2092"
#> [1] "running downsamplePair for synthetic cell 2093"
#> [1] "running downsamplePair for synthetic cell 2094"
#> [1] "running downsamplePair for synthetic cell 2095"
#> [1] "Normalizing..."
#> [1] "Running PCA..."
#> [1] "Clustering augmented data set with Phenograph..."
#> [1] "Setting directed to FALSE because prune is TRUE"
#> Run Rphenograph starts:
#>   -Input data of 10476 rows and 30 columns
#>   -k is set to 30
#>   Finding nearest neighbors...DONE ~ 4.387 s
#>   Compute jaccard coefficient between nearest-neighbor sets...DONE ~ 3.963 s
#>   Build undirected graph from the weighted links...Removing non-symmetric links...DONE ~ 1626.84 s
#>   Run louvain clustering on the graph ...DONE ~ 23.863 s
#> Run Rphenograph DONE, totally takes 1659.05300000001s.
#>   Return a community class
#>   -Modularity value: 0.8274768 
#>   -Number of clusters: 16
#> Error in sizes(fullcommunities[[2]]): could not find function "sizes"

print(paste("Time elapsed", end-start,"seconds,", (end-start) / clf.n_iters, clf.n_iters), "sec/iteration, for", n_inters, "iterations")
#> Error in paste("Time elapsed", end - start, "seconds,", (end - start)/clf.n_iters, : object 'clf.n_iters' not found

Visualize Results

Convergence of Doublet Calls

DoubletDetection::convergence(clf, save='convergence_test.pdf', show=TRUE)
#> [1] "Saving tSNE plot as file: convergence_test.pdf"

#> [[1]]
#> [1] 8381
#> 
#> [[2]]
#> [1] 8381
#> 
#> [[3]]
#> [1] 8381
#> 
#> [[4]]
#> [1] 8381
#> 
#> [[5]]
#> [1] 8381
#> 
#> [[6]]
#> [1] 8381
#> 
#> [[7]]
#> [1] 8381
#> 
#> [[8]]
#> [1] 8381
#> 
#> [[9]]
#> [1] 8381
#> 
#> [[10]]
#> [1] 8381
#> 
#> [[11]]
#> [1] 8381
#> 
#> [[12]]
#> [1] 8381
#> 
#> [[13]]
#> [1] 8381
#> 
#> [[14]]
#> [1] 8381
#> 
#> [[15]]
#> [1] 8381
#> 
#> [[16]]
#> [1] 8381
#> 
#> [[17]]
#> [1] 8381
#> 
#> [[18]]
#> [1] 8381
#> 
#> [[19]]
#> [1] 8381
#> 
#> [[20]]
#> [1] 8381
#> 
#> [[21]]
#> [1] 8381
#> 
#> [[22]]
#> [1] 8381
#> 
#> [[23]]
#> [1] 8381
#> 
#> [[24]]
#> [1] 8381
#> 
#> [[25]]
#> [1] 8381
#> 
#> [[26]]
#> [1] 8381
#> 
#> [[27]]
#> [1] 8381
#> 
#> [[28]]
#> [1] 8381
#> 
#> [[29]]
#> [1] 8381
#> 
#> [[30]]
#> [1] 8381
#> 
#> [[31]]
#> [1] 8381
#> 
#> [[32]]
#> [1] 8381
#> 
#> [[33]]
#> [1] 8381
#> 
#> [[34]]
#> [1] 8381
#> 
#> [[35]]
#> [1] 8381
#> 
#> [[36]]
#> [1] 8381
#> 
#> [[37]]
#> [1] 8381
#> 
#> [[38]]
#> [1] 8381
#> 
#> [[39]]
#> [1] 8381
#> 
#> [[40]]
#> [1] 8381
#> 
#> [[41]]
#> [1] 8381
#> 
#> [[42]]
#> [1] 8381
#> 
#> [[43]]
#> [1] 8381
#> 
#> [[44]]
#> [1] 8381
#> 
#> [[45]]
#> [1] 8381
#> 
#> [[46]]
#> [1] 8381
#> 
#> [[47]]
#> [1] 8381
#> 
#> [[48]]
#> [1] 8381
#> 
#> [[49]]
#> [1] 8381
#> 
#> [[50]]
#> [1] 8381

Doublets on tSNE map

tsne_coords <- DoubletDetection::tsne_plot(raw_counts, doublets, save='tsne_test.pdf', show=True)
#> Error in prcomp(aug_counts, rank = n_components, center = TRUE, scale. = TRUE): object 'aug_counts' not found